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A Comparison of Subjective Estimations and Objective Velocities at Quantifying Proximity to Failure for the Bench Press in Resistance-Trained Men and Women.
Hickmott LM, Butcher SJ, Chilibeck PD. Hickmott LM, et al. J Strength Cond Res. 2024 Apr 9. doi: 10.1519/JSC.0000000000004784. Online ahead of print. J Strength Cond Res. 2024. PMID: 38595310
Hickmott, LM, Butcher, SJ, and Chilibeck, PD. A comparison of subjective estimations and objective velocities at quantifying proximity to failure for the bench press in resistance-trained men and women. ...The dependent variable for the subjective estimations condition was …
Hickmott, LM, Butcher, SJ, and Chilibeck, PD. A comparison of subjective estimations and objective velocities at quantifying proximit …
Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis.
Barbour SJ, Coppo R, Er L, Pillebout E, Russo ML, Alpers CE, Fogo AB, Ferrario F, Jennette JC, Roberts ISD, Cook HT, Ding J, Su B, Zhong X, Fervenza FC, Zand L, Peruzzi L, Lucchetti L, Katafuchi R, Shima Y, Yoshikawa N, Ichikawa D, Suzuki Y, Murer L, Wyatt RJ, Park C, Nelson RD, Narus JH, Wenderfer S, Geetha D, Daugas E, Monteiro RC, Nakatani S, Mastrangelo A, Nuutinen M, Koskela M, Weber LT, Hackl A, Pohl M, Pecoraro C, Tsuboi N, Yokoo T, Takafumi I, Fujimoto S, Conti G, Santoro D, Materassi M, Zhang H, Shi S, Liu ZH, Tesar V, Maixnerova D, Avila-Casado C, Bajema I, Barreca A, Becker JU, Comstock JM, Cornea V, Eldin K, Hernandez LH, Hou J, Joh K, Lin M, Messias N, Muda AO, Pagni F, Diomedi-Camassei F, Tokola H, D'Armiento M, Seidl M, Rosenberg A, Sannier A, Soares MF, Wang S, Zeng C, Haas M. Barbour SJ, et al. Clin J Am Soc Nephrol. 2024 Apr 1;19(4):438-451. doi: 10.2215/CJN.0000000000000398. Epub 2024 Jan 23. Clin J Am Soc Nephrol. 2024. PMID: 38261310
Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cancer.
Crespo-Bravo M, Thorlacius-Ussing J, Nissen NI, Pedersen RS, Boisen MK, Liljefors M, Johansen AZ, Johansen JS, Karsdal MA, Willumsen N. Crespo-Bravo M, et al. BMC Cancer. 2023 Oct 6;23(1):949. doi: 10.1186/s12885-023-11470-5. BMC Cancer. 2023. PMID: 37803411 Free PMC article.
When evaluated by multivariate Cox regression analysis, high PRO-C17 was predictive for poor OS independent of risk factors and the tumor fibrosis biomarker PRO-C3. CONCLUSION: PRO-C17 measures the ectodomain of type XVII collagen in serum and is a promising non-invasive b …
When evaluated by multivariate Cox regression analysis, high PRO-C17 was predictive for poor OS independent of risk factors and the tumor fi …
Mosunetuzumab monotherapy is active and tolerable in patients with relapsed/refractory diffuse large B-cell lymphoma.
Bartlett NL, Assouline S, Giri P, Schuster SJ, Cheah CY, Matasar M, Gregory GP, Yoon DH, Shadman M, Fay K, Yoon SS, Panizo C, Flinn I, Johnston A, Bosch F, Sehn LH, Wei MC, Yin S, To I, Li CC, Huang H, Kwan A, Penuel E, Budde LE. Bartlett NL, et al. Blood Adv. 2023 Sep 12;7(17):4926-4935. doi: 10.1182/bloodadvances.2022009260. Blood Adv. 2023. PMID: 37067952 Free PMC article.
Intravenous mosunetuzumab was administered with cycle (C) 1 step-up dosing for cytokine release syndrome (CRS) mitigation: C1 day (D) 1: 1 mg; C1D8 2 mg; C1D15 and C2D1: 60 mg; C3 + D1: 30 mg. Hospitalization was not mandatory. Patients with complete response (CR) complete …
Intravenous mosunetuzumab was administered with cycle (C) 1 step-up dosing for cytokine release syndrome (CRS) mitigation: C1 day (D) 1: 1 m …
SAR443809: a selective inhibitor of the complement alternative pathway, targeting complement factor Bb.
Rajagopal V, Leksa N, Gorham R, Jindal S, Nair S, Knockenhauer K, Chan J, Byun T, Mercadante C, Moore S, Panicker S, Parry G, Storek M. Rajagopal V, et al. Blood Adv. 2023 Aug 22;7(16):4258-4268. doi: 10.1182/bloodadvances.2022009028. Blood Adv. 2023. PMID: 36897252 Free PMC article.
We describe the discovery of SAR443809, a specific inhibitor of the alternative pathway C3/C5 convertase (C3bBb). SAR443809 selectively binds to the activated form of factor B (factor Bb) and inhibits alternative pathway activity by blocking the cleavage of C3, leav …
We describe the discovery of SAR443809, a specific inhibitor of the alternative pathway C3/C5 convertase (C3bBb). SAR443809 selective …
Type XXII Collagen Complements Fibrillar Collagens in the Serological Assessment of Tumor Fibrosis and the Outcome in Pancreatic Cancer.
Madsen EA, Thorlacius-Ussing J, Nissen NI, Jensen C, Chen IM, Johansen JS, Diab HMH, Jørgensen LN, Hansen CP, Karsdal MA, Willumsen N. Madsen EA, et al. Cells. 2022 Nov 24;11(23):3763. doi: 10.3390/cells11233763. Cells. 2022. PMID: 36497023 Free PMC article.
Circulating fragments of type III collagen, measured by PRO-C3, has shown promising results as a tumor fibrosis biomarker. However, the fibrotic tumor microenvironment consists of many other collagens with diverse functions and unexplored biomarker potential. ...Furthermor …
Circulating fragments of type III collagen, measured by PRO-C3, has shown promising results as a tumor fibrosis biomarker. However, t …
Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia.
Subramanian C, Frank MW, Tangallapally R, Yun MK, White SW, Lee RE, Rock CO, Jackowski S. Subramanian C, et al. J Inherit Metab Dis. 2023 Jan;46(1):28-42. doi: 10.1002/jimd.12570. Epub 2022 Nov 3. J Inherit Metab Dis. 2023. PMID: 36251252 Free PMC article.
Hepatic propionyl-CoA is also reduced by BBP-671 leading to an improved intracellular C3:C2-CoA ratio. Elevated plasma C3:C2-carnitine ratio and methylcitrate, hallmark biomarkers of PA, are significantly reduced by BBP-671. ...
Hepatic propionyl-CoA is also reduced by BBP-671 leading to an improved intracellular C3:C2-CoA ratio. Elevated plasma C3:C2-c …
Plasma Kallikrein-Activated TGF-β Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis.
Pedersen RS, Nissen NI, Jensen C, Thorlacius-Ussing J, Manon-Jensen T, Olesen ML, Langholm LL, Diab HMH, Jorgensen LN, Hansen CP, Chen IM, Johansen JS, Karsdal MA, Willumsen N. Pedersen RS, et al. Biomolecules. 2022 Sep 17;12(9):1315. doi: 10.3390/biom12091315. Biomolecules. 2022. PMID: 36139154 Free PMC article.

Biomarker levels were correlated with overall survival (OS) and compared to serum type III collagen (PRO-C3) and type VI collagen (PRO-C6) pro-peptides. PLK-cleaved LAP-TGF-beta was higher in patients with PDAC compared to healthy individuals (p < 0.0001). ...High level

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Biomarker levels were correlated with overall survival (OS) and compared to serum type III collagen (PRO-C3) and type VI collagen (PR …
Collagen Biomarkers Quantify Fibroblast Activity In Vitro and Predict Survival in Patients with Pancreatic Ductal Adenocarcinoma.
Nissen NI, Johansen AZ, Chen I, Johansen JS, Pedersen RS, Hansen CP, Karsdal MA, Willumsen N. Nissen NI, et al. Cancers (Basel). 2022 Feb 6;14(3):819. doi: 10.3390/cancers14030819. Cancers (Basel). 2022. PMID: 35159087 Free PMC article.
PRO-C3 and PRO-C6 were upregulated in CAFs compared to PFs (p < 0.0001.). TGF-ss1 increased PRO-C3 in both PFs and CAFs (p < 0.0001). The anti-fibrotic compound ALK5i inhibited both PRO-C3 and PRO-C6 (p < 0.0001). ...

PRO-C3 and PRO-C6 were upregulated in CAFs compared to PFs (p < 0.0001.). TGF-ss1 increased PRO-C3 in both PFs and CAFs (p

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49 results