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278 results
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Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis; effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Prakash NJ, Schechter PJ, Mamont PS, Grove J, Koch-Weser J, Sjoerdsma A. Prakash NJ, et al. Among authors: sjoerdsma a. Life Sci. 1980 Jan 21;26(3):181-94. doi: 10.1016/0024-3205(80)90292-1. Life Sci. 1980. PMID: 7360002 No abstract available.
Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid).
Grove J, Schechter PJ, Tell G, Koch-Weser J, Sjoerdsma A, Warter JM, Marescaux C, Rumbach L. Grove J, et al. Among authors: sjoerdsma a. Life Sci. 1981 May 21;28(21):2431-9. doi: 10.1016/0024-3205(81)90511-7. Life Sci. 1981. PMID: 6789022 No abstract available.
Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.
Luk GD, Sharkis SJ, Abeloff MD, McCann PP, Sjoerdsma A, Baylin SB. Luk GD, et al. Among authors: sjoerdsma a. Proc Natl Acad Sci U S A. 1983 Aug;80(16):5090-3. doi: 10.1073/pnas.80.16.5090. Proc Natl Acad Sci U S A. 1983. PMID: 6410400 Free PMC article.
Effects of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor or ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated rats.
Danzin C, Jung MJ, Claverie N, Grove J, Sjoerdsma A, Koch-Weser J. Danzin C, et al. Among authors: sjoerdsma a. Biochem J. 1979 Jun 15;180(3):507-13. doi: 10.1042/bj1800507. Biochem J. 1979. PMID: 486129 Free PMC article.
Chemotherapeutic implications of polyamine biosynthesis inhibition.
Sjoerdsma A, Schechter PJ. Sjoerdsma A, et al. Clin Pharmacol Ther. 1984 Mar;35(3):287-300. doi: 10.1038/clpt.1984.33. Clin Pharmacol Ther. 1984. PMID: 6421528 Review. No abstract available.
Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.
Abeloff MD, Slavik M, Luk GD, Griffin CA, Hermann J, Blanc O, Sjoerdsma A, Baylin SB. Abeloff MD, et al. Among authors: sjoerdsma a. J Clin Oncol. 1984 Feb;2(2):124-30. doi: 10.1200/JCO.1984.2.2.124. J Clin Oncol. 1984. PMID: 6422008
Decarboxylated-S-adenosylmethionine excretion: a biochemical marker of ornithine decarboxylase inhibition by alpha-difluoromethylornithine.
Haegele KD, Splinter TA, Romijn JC, Schechter PJ, Sjoerdsma A. Haegele KD, et al. Among authors: sjoerdsma a. Cancer Res. 1987 Feb 1;47(3):890-5. Cancer Res. 1987. PMID: 3100028
L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis.
Fozard JR, Part ML, Prakash NJ, Grove J, Schechter PJ, Sjoerdsma A, Koch-Weser J. Fozard JR, et al. Among authors: sjoerdsma a. Science. 1980 May 2;208(4443):505-8. doi: 10.1126/science.6768132. Science. 1980. PMID: 6768132
Inhibition of growth of Mycoplasma dispar by DL-alpha-difluoromethyllsine, a selective irreversible inhibitor of lysine decarboxylase, and reversal by cadaverine (1,5-diaminopentane).
Pösö H, McCann PP, Tanskanen R, Bey P, Sjoerdsma A. Pösö H, et al. Among authors: sjoerdsma a. Biochem Biophys Res Commun. 1984 Nov 30;125(1):205-10. doi: 10.1016/s0006-291x(84)80355-1. Biochem Biophys Res Commun. 1984. PMID: 6439203
Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
Marton LJ, Levin VA, Hervatin SJ, Koch-Weser J, McCann PP, Sjoerdsma A. Marton LJ, et al. Among authors: sjoerdsma a. Cancer Res. 1981 Nov;41(11 Pt 1):4426-31. Cancer Res. 1981. PMID: 6796258
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