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A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP.
Skovronsky DM, Pijak DS, Doms RW, Lee VM. Skovronsky DM, et al. Biochemistry. 2000 Feb 1;39(4):810-7. doi: 10.1021/bi991728z. Biochemistry. 2000. PMID: 10651647
Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain.
Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF. Choi SR, et al. Among authors: skovronsky d. J Nucl Med. 2009 Nov;50(11):1887-94. doi: 10.2967/jnumed.109.065284. Epub 2009 Oct 16. J Nucl Med. 2009. PMID: 19837759 Free PMC article.
IBOX(2-(4'-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain.
Zhuang ZP, Kung MP, Hou C, Plössl K, Skovronsky D, Gur TL, Trojanowski JQ, Lee VM, Kung HF. Zhuang ZP, et al. Among authors: skovronsky d. Nucl Med Biol. 2001 Nov;28(8):887-94. doi: 10.1016/s0969-8051(01)00264-5. Nucl Med Biol. 2001. PMID: 11711307
Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.
Lee CW, Zhuang ZP, Kung MP, Plössl K, Skovronsky D, Gur T, Hou C, Trojanowski JQ, Lee VM, Kung HF. Lee CW, et al. Among authors: skovronsky d. J Med Chem. 2001 Jul 5;44(14):2270-5. doi: 10.1021/jm010161t. J Med Chem. 2001. PMID: 11428920
The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains.
Schmidt ML, Schuck T, Sheridan S, Kung MP, Kung H, Zhuang ZP, Bergeron C, Lamarche JS, Skovronsky D, Giasson BI, Lee VM, Trojanowski JQ. Schmidt ML, et al. Among authors: skovronsky d. Am J Pathol. 2001 Sep;159(3):937-43. doi: 10.1016/s0002-9440(10)61769-5. Am J Pathol. 2001. PMID: 11549586 Free PMC article.
Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques.
Skovronsky DM, Fath S, Lee VM, Milla ME. Skovronsky DM, et al. J Neurobiol. 2001 Oct;49(1):40-6. doi: 10.1002/neu.1064. J Neurobiol. 2001. PMID: 11536196
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Zhuang ZP, Kung MP, Hou C, Skovronsky DM, Gur TL, Plössl K, Trojanowski JQ, Lee VM, Kung HF. Zhuang ZP, et al. Among authors: skovronsky dm. J Med Chem. 2001 Jun 7;44(12):1905-14. doi: 10.1021/jm010045q. J Med Chem. 2001. PMID: 11384236
Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C.
Skovronsky DM, Lee VM, Praticò D. Skovronsky DM, et al. J Biol Chem. 2001 May 18;276(20):17036-43. doi: 10.1074/jbc.M006285200. Epub 2001 Mar 5. J Biol Chem. 2001. PMID: 11278299
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.
Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM. Skovronsky DM, et al. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7609-14. doi: 10.1073/pnas.97.13.7609. Proc Natl Acad Sci U S A. 2000. PMID: 10861023 Free PMC article.
Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease.
Skovronsky DM, Lee VM. Skovronsky DM, et al. Trends Pharmacol Sci. 2000 May;21(5):161-3. doi: 10.1016/s0165-6147(00)01467-x. Trends Pharmacol Sci. 2000. PMID: 10785643 No abstract available.
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