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Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.
Dantzig AH, Shepard RL, Pratt SE, Tabas LB, Lander PA, Ma L, Paul DC, Williams DC, Peng SB, Slapak CA, Godinot N, Perry WL 3rd. Dantzig AH, et al. Among authors: slapak ca. Biochem Pharmacol. 2004 Mar 15;67(6):1111-21. doi: 10.1016/j.bcp.2003.11.006. Biochem Pharmacol. 2004. PMID: 15006547
Role of P-glycoprotein in dolastatin 10 resistance.
Toppmeyer DL, Slapak CA, Croop J, Kufe DW. Toppmeyer DL, et al. Among authors: slapak ca. Biochem Pharmacol. 1994 Aug 3;48(3):609-12. doi: 10.1016/0006-2952(94)90292-5. Biochem Pharmacol. 1994. PMID: 7915113
A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients with advanced malignancy.
Sandler A, Gordon M, De Alwis DP, Pouliquen I, Green L, Marder P, Chaudhary A, Fife K, Battiato L, Sweeney C, Jordan C, Burgess M, Slapak CA. Sandler A, et al. Among authors: slapak ca. Clin Cancer Res. 2004 May 15;10(10):3265-72. doi: 10.1158/1078-0432.CCR-03-0644. Clin Cancer Res. 2004. PMID: 15161679 Clinical Trial.
40 results