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Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence.
Dhiman RK, Mahapatra S, Slayden RA, Boyne ME, Lenaerts A, Hinshaw JC, Angala SK, Chatterjee D, Biswas K, Narayanasamy P, Kurosu M, Crick DC. Dhiman RK, et al. Mol Microbiol. 2009 Apr;72(1):85-97. doi: 10.1111/j.1365-2958.2009.06625.x. Epub 2009 Feb 11. Mol Microbiol. 2009. PMID: 19220750 Free PMC article.
Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors.
Boyne ME, Sullivan TJ, amEnde CW, Lu H, Gruppo V, Heaslip D, Amin AG, Chatterjee D, Lenaerts A, Tonge PJ, Slayden RA. Boyne ME, et al. Antimicrob Agents Chemother. 2007 Oct;51(10):3562-7. doi: 10.1128/AAC.00383-07. Epub 2007 Jul 30. Antimicrob Agents Chemother. 2007. PMID: 17664324 Free PMC article.
Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.
Thanna S, Knudson SE, Grzegorzewicz A, Kapil S, Goins CM, Ronning DR, Jackson M, Slayden RA, Sucheck SJ. Thanna S, et al. Among authors: slayden ra. Org Biomol Chem. 2016 Jul 7;14(25):6119-6133. doi: 10.1039/c6ob00821f. Epub 2016 Jun 2. Org Biomol Chem. 2016. PMID: 27251120 Free PMC article.
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.
Sullivan TJ, Truglio JJ, Boyne ME, Novichenok P, Zhang X, Stratton CF, Li HJ, Kaur T, Amin A, Johnson F, Slayden RA, Kisker C, Tonge PJ. Sullivan TJ, et al. ACS Chem Biol. 2006 Feb 17;1(1):43-53. doi: 10.1021/cb0500042. ACS Chem Biol. 2006. PMID: 17163639
Analysis of the Lipids of Mycobacterium tuberculosis.
Slayden RA, Barry CE 3rd. Slayden RA, et al. Methods Mol Med. 2001;54:229-45. doi: 10.1385/1-59259-147-7:229. Methods Mol Med. 2001. PMID: 21341079
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis.
Barry CE 3rd, Slayden RA, Mdluli K. Barry CE 3rd, et al. Drug Resist Updat. 1998;1(2):128-34. doi: 10.1016/s1368-7646(98)80028-9. Drug Resist Updat. 1998. PMID: 16904399
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