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Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. IUBMB Life. 2006 Apr;58(4):217-23. doi: 10.1080/15216540600732021. IUBMB Life. 2006. PMID: 16754300
Here, we report on the role of cPLA2 in the disturbances in gastric mucin synthesis evoked by the LPS of H. pylori, a bacterium identified as a primary cause of gastric disease. Using rat gastric mucosal cells, we show that H. pylori LPS detrimental effect on gastri …
Here, we report on the role of cPLA2 in the disturbances in gastric mucin synthesis evoked by the LPS of H. pylori, a bacterium ident …
Effect of ebrotidine on gastric mucosal calcium channel activity.
Slomiany BL, Liu J, Kawai T, Czajkowski A, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. Am J Gastroenterol. 1993 Jun;88(6):881-6. Am J Gastroenterol. 1993. PMID: 8099251
Ebrotidine is a new H2-receptor antagonist also known for its gastroprotective effect against ethanol-induced mucosal injury. ...Maximum inhibitory effect was attained at 50 micrograms/ml ebrotidine, at which point a 54.9% decrease in uptake occurred. The gastric mu …
Ebrotidine is a new H2-receptor antagonist also known for its gastroprotective effect against ethanol-induced mucosal injury. ...Maxi …
Mechanism of Cytosolic Phospholipase A(2) Activation in Ghrelin Protection of Salivary Gland Acinar Cells against Ethanol Cytotoxicity.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. Adv Pharmacol Sci. 2010;2010:269274. doi: 10.1155/2010/269274. Epub 2010 Jun 22. Adv Pharmacol Sci. 2010. PMID: 21152208 Free PMC article.
Ghrelin, a peptide hormone, newly identified in oral mucosal tissues, has emerged recently as an important mediator of the processes of mucosal defense. ...The protective effect of ghrelin was associated with the increase in NO and PGE2, and upregulation in cytosolic phosp …
Ghrelin, a peptide hormone, newly identified in oral mucosal tissues, has emerged recently as an important mediator of the processes …
Ghrelin Protection against Cytotoxic Effect of Ethanol on Rat Salivary Mucin Synthesis involves Cytosolic Phospholipase A2 Activation through S-Nitrosylation.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. Int J Biomed Sci. 2010 Mar;6(1):37-44. Int J Biomed Sci. 2010. PMID: 23675174 Free PMC article.
Recent advances in identifying the salivary constituents of significance to the maintenance of soft oral tissue integrity have brought to focus the importance of a 28-amino acid peptide hormone, ghrelin. ...
Recent advances in identifying the salivary constituents of significance to the maintenance of soft oral tissue integrity have brought to fo …
Helicobacter pylori Induces Disturbances in Gastric Mucosal Akt Activation through Inducible Nitric Oxide Synthase-Dependent S-Nitrosylation: Effect of Ghrelin.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. ISRN Gastroenterol. 2011;2011:308727. doi: 10.5402/2011/308727. Epub 2010 Nov 4. ISRN Gastroenterol. 2011. PMID: 21991502 Free PMC article.
Gastric mucosal inflammatory response to H. pylori and its key virulence factor, lipopolysaccharide (LPS), are characterized by a massive rise in apoptosis and the disturbances in NO signaling pathways. ...We also report that ghrelin protection against H. pylori-induced di …
Gastric mucosal inflammatory response to H. pylori and its key virulence factor, lipopolysaccharide (LPS), are characterized by a mas …
Suppression by Ghrelin of Porphyromonas gingivalis-Induced Constitutive Nitric Oxide Synthase S-Nitrosylation and Apoptosis in Salivary Gland Acinar Cells.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. J Signal Transduct. 2010;2010:643642. doi: 10.1155/2010/643642. Epub 2010 Sep 1. J Signal Transduct. 2010. PMID: 21637354 Free PMC article.
Oral mucosal inflammatory responses to periodontopathic bacterium, P. gingivalis, and its key virulence factor, LPS, are characterized by a massive rise in epithelial cell apoptosis and the disturbances in NO signaling pathways. ...We also show that ghrelin protection agai …
Oral mucosal inflammatory responses to periodontopathic bacterium, P. gingivalis, and its key virulence factor, LPS, are characterized by …
Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin Synthesis.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. Int J Inflam. 2011;2011:807279. doi: 10.4061/2011/807279. Epub 2011 Apr 6. Int J Inflam. 2011. PMID: 21603133 Free PMC article.
In this study, using rat sublingual gland acinar cells, we report that P. gingivalis LPS-induced impairment in mucin synthesis and associated suppression in Akt kinase activity were accompanied by a decrease in constitutive nitric oxide synthase (cNOS) activity and an indu …
In this study, using rat sublingual gland acinar cells, we report that P. gingivalis LPS-induced impairment in mucin synthesis and associate …
Ghrelin protection against lipopolysaccharide-induced gastric mucosal cell apoptosis involves constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. Mediators Inflamm. 2010;2010:280464. doi: 10.1155/2010/280464. Epub 2010 Mar 30. Mediators Inflamm. 2010. PMID: 20369000 Free PMC article.
Ghrelin, a peptide hormone produced mainly in the stomach, has emerged as an important modulator of the inflammatory responses that are of significance to the maintenance of gastric mucosal integrity. ...
Ghrelin, a peptide hormone produced mainly in the stomach, has emerged as an important modulator of the inflammatory responses that a …
Endothelin-1-dependent up-regulation of leptin production in gastric mucosal injury by indomethacin.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. Inflammopharmacology. 2005;13(5-6):455-66. doi: 10.1163/156856005774649331. Inflammopharmacology. 2005. PMID: 16280098
Moreover, a marked drop in the mucosal level of leptin and the reduction in the severity of mucosal damage was attained following pretreatment with ET(A) receptor antagonist BQ610, but not by ET(B) receptor antagonist BQ788. The results implicate ET-1 as a ke …
Moreover, a marked drop in the mucosal level of leptin and the reduction in the severity of mucosal damage was attained following pre …
Up-regulation in endothelin-1 by Helicobacter pylori lipopolysaccharide interferes with gastric mucin synthesis via epidermal growth factor receptor transactivation.
Slomiany BL, Slomiany A. Slomiany BL, et al. Among authors: slomiany a. Scand J Gastroenterol. 2005 Aug;40(8):921-28. doi: 10.1080/00365520510015890. Scand J Gastroenterol. 2005. PMID: 16173126
OBJECTIVE: Endothelin-1 (ET-1), a key mediator of inflammatory processes associated with bacterial infection, is a 21-amino acid peptide produced from a biologically inactive big ET-1 by the action of endothelin-converting enzyme-1 (ECE-1) that acts through G …
OBJECTIVE: Endothelin-1 (ET-1), a key mediator of inflammatory processes associated with bacterial infection, is a 21-amino ac …
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