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History of Mechanical Ventilation. From Vesalius to Ventilator-induced Lung Injury.
Slutsky AS. Slutsky AS. Am J Respir Crit Care Med. 2015 May 15;191(10):1106-15. doi: 10.1164/rccm.201503-0421PP. Am J Respir Crit Care Med. 2015. PMID: 25844759
One of the great advances in ventilatory support over the past few decades has been the development of lung-protective ventilatory strategies, based on our understanding of the iatrogenic consequences of mechanical ventilation such as ventilator-induced lung injury. ...
One of the great advances in ventilatory support over the past few decades has been the development of lung-protective ventilatory strategie …
Occult, occult auto-PEEP in status asthmaticus.
Stewart TE, Slutsky AS. Stewart TE, et al. Crit Care Med. 1996 Mar;24(3):379-80. doi: 10.1097/00003246-199603000-00003. Crit Care Med. 1996. PMID: 8625622 Review. No abstract available.
Impairment of lung and chest wall mechanics in patients with acute respiratory distress syndrome: role of abdominal distension.
Ranieri VM, Brienza N, Santostasi S, Puntillo F, Mascia L, Vitale N, Giuliani R, Memeo V, Bruno F, Fiore T, Brienza A, Slutsky AS. Ranieri VM, et al. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1082-91. doi: 10.1164/ajrccm.156.4.97-01052. Am J Respir Crit Care Med. 1997. PMID: 9351606
Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group.
Stewart TE, Meade MO, Cook DJ, Granton JT, Hodder RV, Lapinsky SE, Mazer CD, McLean RF, Rogovein TS, Schouten BD, Todd TR, Slutsky AS. Stewart TE, et al. N Engl J Med. 1998 Feb 5;338(6):355-61. doi: 10.1056/NEJM199802053380603. N Engl J Med. 1998. PMID: 9449728 Clinical Trial.
METHODS: Within 24 hours of intubation, patients at high risk for the acute respiratory distress syndrome were randomly assigned to either pressure- and volume-limited ventilation (limited-ventilation group), with the peak inspiratory pressure maintained at 30 cm of water or less …
METHODS: Within 24 hours of intubation, patients at high risk for the acute respiratory distress syndrome were randomly assigned to either p …
A computed tomography scan assessment of regional lung volume in acute lung injury. The CT Scan ARDS Study Group.
Puybasset L, Cluzel P, Chao N, Slutsky AS, Coriat P, Rouby JJ. Puybasset L, et al. Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1644-55. doi: 10.1164/ajrccm.158.5.9802003. Am J Respir Crit Care Med. 1998. PMID: 9817720
Has high-frequency ventilation been inappropriately discarded in adult acute respiratory distress syndrome?
Herridge MS, Slutsky AS, Colditz GA. Herridge MS, et al. Crit Care Med. 1998 Dec;26(12):2073-7. doi: 10.1097/00003246-199812000-00044. Crit Care Med. 1998. PMID: 9875923 Review.
CONCLUSIONS: Current clinical studies are statistically under-powered and a metasummary is not feasible because of study quality, as well as lack of similar clinical end points and measures of magnitude of benefit. ...
CONCLUSIONS: Current clinical studies are statistically under-powered and a metasummary is not feasible because of study quality, as
Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial.
Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS. Ranieri VM, et al. JAMA. 1999 Jul 7;282(1):54-61. doi: 10.1001/jama.282.1.54. JAMA. 1999. PMID: 10404912 Clinical Trial.
Ventilator-induced lung injury: more studies, more questions.
Kavanagh BP, Slutsky AS. Kavanagh BP, et al. Crit Care Med. 1999 Aug;27(8):1669-71. doi: 10.1097/00003246-199908000-00059. Crit Care Med. 1999. PMID: 10470791 Review. No abstract available.
Lung recruitment during small tidal volume ventilation allows minimal positive end-expiratory pressure without augmenting lung injury.
Rimensberger PC, Pristine G, Mullen BM, Cox PN, Slutsky AS. Rimensberger PC, et al. Crit Care Med. 1999 Sep;27(9):1940-5. doi: 10.1097/00003246-199909000-00037. Crit Care Med. 1999. PMID: 10507622

One group (group 1) served as a control; their lungs were inflated at PEEP < P(inf) but not ventilated. The other three groups were ventilated with small tidal volumes (5 to 6 mL/kg) for 2 hrs with the following interventions: group 2, PEEP < P(inf) without SI; group

One group (group 1) served as a control; their lungs were inflated at PEEP < P(inf) but not ventilated. The other three groups wer

Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome.
Meade MO, Cook RJ, Guyatt GH, Groll R, Kachura JR, Bedard M, Cook DJ, Slutsky AS, Stewart TE. Meade MO, et al. Am J Respir Crit Care Med. 2000 Jan;161(1):85-90. doi: 10.1164/ajrccm.161.1.9809003. Am J Respir Crit Care Med. 2000. PMID: 10619802 Clinical Trial.
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