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Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells.
Kim Y, Kang K, Lee SB, Seo D, Yoon S, Kim SJ, Jang K, Jung YK, Lee KG, Factor VM, Jeong J, Choi D. Kim Y, et al. J Hepatol. 2019 Jan;70(1):97-107. doi: 10.1016/j.jhep.2018.09.007. Epub 2018 Sep 19. J Hepatol. 2019. PMID: 30240598
METHODS: Human hepatocytes were isolated from healthy and diseased donor livers and reprogrammed into progenitor cells by 2 small molecules, A83-01 and CHIR99021 (AC), in the presence of EGF and HGF. ...LAY SUMMARY: Human primary …
METHODS: Human hepatocytes were isolated from healthy and diseased donor livers and reprogrammed into progenitor
Hepatic patch by stacking patient-specific liver progenitor cell sheets formed on multiscale electrospun fibers promotes regenerative therapy for liver injury.
Kim Y, Kim YW, Lee SB, Kang K, Yoon S, Choi D, Park SH, Jeong J. Kim Y, et al. Biomaterials. 2021 Jul;274:120899. doi: 10.1016/j.biomaterials.2021.120899. Epub 2021 May 18. Biomaterials. 2021. PMID: 34034028 Free article.
However, renewable and scalable cell sources for engineered tissue patches remain limited. We previously reported a new type of proliferating bipotent human chemically derived hepatic progenitor cells (hCdHs) developed by small molecule- …
However, renewable and scalable cell sources for engineered tissue patches remain limited. We previously reported a new type of proliferatin …