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Ghrelin induces adiposity in rodents.
Tschöp M, Smiley DL, Heiman ML. Tschöp M, et al. Among authors: smiley dl. Nature. 2000 Oct 19;407(6806):908-13. doi: 10.1038/35038090. Nature. 2000. PMID: 11057670
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. Day JW, et al. Among authors: smiley d. Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597507
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH. Müller TD, et al. Among authors: smiley d. Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968. Nat Commun. 2013. PMID: 23744028 Free PMC article.
Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors.
Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tschöp MH, Sandoval DA, Perez-Tilve D. Heppner KM, et al. Among authors: smiley dl. Diabetes. 2014 Jan;63(1):122-31. doi: 10.2337/db13-0414. Epub 2013 Sep 23. Diabetes. 2014. PMID: 24062249 Free PMC article.
Ghrelin-induced adiposity is independent of orexigenic effects.
Perez-Tilve D, Heppner K, Kirchner H, Lockie SH, Woods SC, Smiley DL, Tschöp M, Pfluger P. Perez-Tilve D, et al. Among authors: smiley dl. FASEB J. 2011 Aug;25(8):2814-22. doi: 10.1096/fj.11-183632. Epub 2011 May 4. FASEB J. 2011. PMID: 21543764 Free PMC article.
Acylation type determines ghrelin's effects on energy homeostasis in rodents.
Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Heppner KM, et al. Among authors: smiley dl. Endocrinology. 2012 Oct;153(10):4687-95. doi: 10.1210/en.2012-1194. Epub 2012 Aug 3. Endocrinology. 2012. PMID: 22865372 Free PMC article.
A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.
Patterson JT, Ottaway N, Gelfanov VM, Smiley DL, Perez-Tilve D, Pfluger PT, Tschöp MH, Dimarchi RD. Patterson JT, et al. Among authors: smiley dl. ACS Chem Biol. 2011 Feb 18;6(2):135-45. doi: 10.1021/cb1002015. Epub 2010 Nov 4. ACS Chem Biol. 2011. PMID: 20939591
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: smiley dl. Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485909
Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats.
Lugar CW, Clay MP, Lindstrom TD, Woodson AL, Smiley D, Heiman ML, Dodge JA. Lugar CW, et al. Among authors: smiley d. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5873-6. doi: 10.1016/j.bmcl.2004.09.027. Bioorg Med Chem Lett. 2004. PMID: 15501059
Structure-activity relationships of beta-MSH derived melanocortin-4 receptor peptide agonists.
Yan LZ, Hsiung HM, Heiman ML, Gadski RA, Emmerson PJ, Hertel J, Flora D, Edwards P, Smiley D, Zhang L, Husain S, Kahl SD, DiMarchi RD, Mayer JP. Yan LZ, et al. Among authors: smiley d. Curr Top Med Chem. 2007;7(11):1052-67. doi: 10.2174/156802607780906591. Curr Top Med Chem. 2007. PMID: 17584126 Review.
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