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Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions.
Nagy Z, Esiri MM, Smith AD. Nagy Z, et al. Among authors: smith ad. Acta Neuropathol. 1997 Mar;93(3):294-300. doi: 10.1007/s004010050617. Acta Neuropathol. 1997. PMID: 9083562
Neuronal nuclear expression of Ki-67 was increased in AD but was also elevated in young Down's syndrome subjects and in those with Pick's disease. Expression of this protein was therefore not AD-specific. We did not find nuclear pCNA or p53 expressed in our patient …
Neuronal nuclear expression of Ki-67 was increased in AD but was also elevated in young Down's syndrome subjects and in those with Pi …
Association study of MICA and MICB in Alzheimer's disease.
Quiroga I, Lehmann DJ, Barnardo MC, Fuggle S, Cortina-Borja M, Warden DR, Smith AD. Quiroga I, et al. Among authors: smith ad. Tissue Antigens. 2009 Sep;74(3):241-3. doi: 10.1111/j.1399-0039.2009.01297.x. Tissue Antigens. 2009. PMID: 19691640
We found a possible association of MICA*00801 heterozygotes with AD in subjects positive for the epsilon 4 allele of apolipoprotein E. ...In any case, these results do not explain our previously reported association of HLA-B*07 with AD....
We found a possible association of MICA*00801 heterozygotes with AD in subjects positive for the epsilon 4 allele of apolipoprotein E …
Deafferentation of the hippocampus results in the induction of AT8 positive 'granules' in the rat.
Mudher AK, Yee B, Smith AD, Perry VH. Mudher AK, et al. Among authors: smith ad. Neurosci Lett. 2001 Mar 23;301(1):5-8. doi: 10.1016/s0304-3940(01)01593-2. Neurosci Lett. 2001. PMID: 11239703
Using meta-analysis to explain the diversity of results in genetic studies of late-onset Alzheimer's disease and to identify high-risk subgroups.
Lehmann DJ, Williams J, McBroom J, Smith AD. Lehmann DJ, et al. Among authors: smith ad. Neuroscience. 2001;108(4):541-54. doi: 10.1016/s0306-4522(01)00464-x. Neuroscience. 2001. PMID: 11738493
Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer disease: interleukin-1beta, interleukin-6, interleukin-1 receptor antagonist, tumor necrosis factor-alpha, the soluble tumor necrosis factor receptors I and II, and alpha1-antichymotrypsin.
Lanzrein AS, Johnston CM, Perry VH, Jobst KA, King EM, Smith AD. Lanzrein AS, et al. Among authors: smith ad. Alzheimer Dis Assoc Disord. 1998 Sep;12(3):215-27. doi: 10.1097/00002093-199809000-00016. Alzheimer Dis Assoc Disord. 1998. PMID: 9772027
The levels of IL-1beta and IL-6 in the various brain regions were not significantly different in the AD and the non-AD group. ...Low levels of TNF-alpha in the brain areas that showed neuropathology in AD may indicate a dysregulation of the inflammatory proce …
The levels of IL-1beta and IL-6 in the various brain regions were not significantly different in the AD and the non-AD group. …
Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease.
Combrinck M, Williams J, De Berardinis MA, Warden D, Puopolo M, Smith AD, Minghetti L. Combrinck M, et al. Among authors: smith ad. J Neurol Neurosurg Psychiatry. 2006 Jan;77(1):85-8. doi: 10.1136/jnnp.2005.063131. Epub 2005 Jun 8. J Neurol Neurosurg Psychiatry. 2006. PMID: 15944180 Free PMC article.
Low free testosterone is an independent risk factor for Alzheimer's disease.
Hogervorst E, Bandelow S, Combrinck M, Smith AD. Hogervorst E, et al. Among authors: smith ad. Exp Gerontol. 2004 Nov-Dec;39(11-12):1633-9. doi: 10.1016/j.exger.2004.06.019. Exp Gerontol. 2004. PMID: 15582279
Elderly AD cases had raised levels of gonadotropins. This response may be an attempt to normalize low free testosterone levels. ...Lowering SHBG and/or screening for subclinical thyroid disease may prevent cognitive decline and/or wasting in men at risk for AD....
Elderly AD cases had raised levels of gonadotropins. This response may be an attempt to normalize low free testosterone levels. ...Lo …
The validity and reliability of 6 sets of clinical criteria to classify Alzheimer's disease and vascular dementia in cases confirmed post-mortem: added value of a decision tree approach.
Hogervorst E, Bandelow S, Combrinck M, Irani SR, Smith AD. Hogervorst E, et al. Among authors: smith ad. Dement Geriatr Cogn Disord. 2003;16(3):170-80. doi: 10.1159/000071006. Dement Geriatr Cogn Disord. 2003. PMID: 12826744
Cases who had been diagnosed as NINCDS/ADRDA 'probable AD' in life were usually confirmed at autopsy, but half of the NINCDS/ADRDA 'negative' cases were not (low specificity). ...The DSM-IV criteria had good validity for AD when compared with post-mortem confirmatio …
Cases who had been diagnosed as NINCDS/ADRDA 'probable AD' in life were usually confirmed at autopsy, but half of the NINCDS/ADRDA 'n …
Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men.
Lehmann DJ, Butler HT, Warden DR, Combrinck M, King E, Nicoll JA, Budge MM, de Jager CA, Hogervorst E, Esiri MM, Ragoussis J, Smith AD. Lehmann DJ, et al. Among authors: smith ad. Neurosci Lett. 2003 Apr 10;340(2):87-90. doi: 10.1016/s0304-3940(03)00069-7. Neurosci Lett. 2003. PMID: 12668243
We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR pol …
We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: …
Apolipoprotein E epsilon4 and testosterone interact in the risk of Alzheimer's disease in men.
Hogervorst E, Lehmann DJ, Warden DR, McBroom J, Smith AD. Hogervorst E, et al. Among authors: smith ad. Int J Geriatr Psychiatry. 2002 Oct;17(10):938-40. doi: 10.1002/gps.714. Int J Geriatr Psychiatry. 2002. PMID: 12325053
OBJECTIVES: To assess the association between testosterone levels and APOEepsilon4 in cases with AD and controls. METHOD: We included 61 men with definite or probable Alzheimer's disease (AD) and 55 elderly male controls from the Oxford Project to Investigate Memory …
OBJECTIVES: To assess the association between testosterone levels and APOEepsilon4 in cases with AD and controls. METHOD: We included …
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