Smith AJ - Search Results

1

Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors.

Tan MH, Smith AJ, Pawlyk B, Xu X, Liu X, Bainbridge JB, Basche M, McIntosh J, Tran HV, Nathwani A, Li T, Ali RR. Tan MH, et al. Among authors: smith aj. Hum Mol Genet. 2009 Jun 15;18(12):2099-114. doi: 10.1093/hmg/ddp133. Epub 2009 Mar 19. Hum Mol Genet. 2009. PMID: 19299492 Free PMC article.

2

Gene replacement therapy in the retinal degeneration slow (rds) mouse: the effect on retinal degeneration following partial transduction of the retina.

Sarra GM, Stephens C, de Alwis M, Bainbridge JW, Smith AJ, Thrasher AJ, Ali RR. Sarra GM, et al. Among authors: smith aj. Hum Mol Genet. 2001 Oct 1;10(21):2353-61. doi: 10.1093/hmg/10.21.2353. Hum Mol Genet. 2001. PMID: 11689482

3

Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration.

Schlichtenbrede FC, MacNeil A, Bainbridge JW, Tschernutter M, Thrasher AJ, Smith AJ, Ali RR. Schlichtenbrede FC, et al. Among authors: smith aj. Gene Ther. 2003 Mar;10(6):523-7. doi: 10.1038/sj.gt.3301929. Gene Ther. 2003. PMID: 12621456

4

Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina.

Bainbridge JW, Mistry A, Schlichtenbrede FC, Smith A, Broderick C, De Alwis M, Georgiadis A, Taylor PM, Squires M, Sethi C, Charteris D, Thrasher AJ, Sargan D, Ali RR. Bainbridge JW, et al. Among authors: smith a. Gene Ther. 2003 Aug;10(16):1336-44. doi: 10.1038/sj.gt.3301990. Gene Ther. 2003. PMID: 12883530

5

AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa.

Smith AJ, Schlichtenbrede FC, Tschernutter M, Bainbridge JW, Thrasher AJ, Ali RR. Smith AJ, et al. Mol Ther. 2003 Aug;8(2):188-95. doi: 10.1016/s1525-0016(03)00144-8. Mol Ther. 2003. PMID: 12907141 Free article.

6

Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy.

Schlichtenbrede FC, da Cruz L, Stephens C, Smith AJ, Georgiadis A, Thrasher AJ, Bainbridge JW, Seeliger MW, Ali RR. Schlichtenbrede FC, et al. Among authors: smith aj. J Gene Med. 2003 Sep;5(9):757-64. doi: 10.1002/jgm.401. J Gene Med. 2003. PMID: 12950066

7

Improvement of neuronal visual responses in the superior colliculus in Prph2(Rd2/Rd2) mice following gene therapy.

Schlichtenbrede FC, Smith AJ, Bainbridge JW, Thrasher AJ, Salt TE, Ali RR. Schlichtenbrede FC, et al. Among authors: smith aj. Mol Cell Neurosci. 2004 Jan;25(1):103-10. doi: 10.1016/j.mcn.2003.09.020. Mol Cell Neurosci. 2004. PMID: 14962744

8

Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy.

Tschernutter M, Schlichtenbrede FC, Howe S, Balaggan KS, Munro PM, Bainbridge JW, Thrasher AJ, Smith AJ, Ali RR. Tschernutter M, et al. Among authors: smith aj. Gene Ther. 2005 Apr;12(8):694-701. doi: 10.1038/sj.gt.3302460. Gene Ther. 2005. PMID: 15660111

9

Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis.

Broderick CA, Smith AJ, Balaggan KS, Georgiadis A, Buch PK, Trittibach PC, Barker SE, Sarra GM, Thrasher AJ, Dick AD, Ali RR. Broderick CA, et al. Among authors: smith aj. Mol Ther. 2005 Aug;12(2):369-73. doi: 10.1016/j.ymthe.2005.03.018. Mol Ther. 2005. PMID: 16043105 Free article.

10

Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP.

Pawlyk BS, Smith AJ, Buch PK, Adamian M, Hong DH, Sandberg MA, Ali RR, Li T. Pawlyk BS, et al. Among authors: smith aj. Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3039-45. doi: 10.1167/iovs.05-0371. Invest Ophthalmol Vis Sci. 2005. PMID: 16123399

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