Smith DA - Search Results

1

Why do metabolites circulate?

Smith DA, Dalvie D. Smith DA, et al. Xenobiotica. 2012 Jan;42(1):107-26. doi: 10.3109/00498254.2011.630110. Epub 2011 Nov 24. Xenobiotica. 2012. PMID: 22115420 Review.

2

Pfizer Sandwich Laboratories: where drug metabolism first met drug discovery.

Smith D. Smith D. Xenobiotica. 2012 Jan;42(1):2-3. doi: 10.3109/00498254.2012.636210. Xenobiotica. 2012. PMID: 22141758 No abstract available.

3

Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing.

Smith DA, Obach RS. Smith DA, et al. Drug Metab Dispos. 2005 Oct;33(10):1409-17. doi: 10.1124/dmd.105.005041. Epub 2005 Jun 28. Drug Metab Dispos. 2005. PMID: 15985503

4

Are predictive biomarkers of toxicity worth having? An economic model.

Jones B, Smith DA, Schmid EF. Jones B, et al. Among authors: smith da. Xenobiotica. 2012 Jan;42(1):4-10. doi: 10.3109/00498254.2011.616938. Epub 2011 Oct 4. Xenobiotica. 2012. PMID: 21970747

5

Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment.

Smith DA, Obach RS. Smith DA, et al. Chem Res Toxicol. 2009 Feb;22(2):267-79. doi: 10.1021/tx800415j. Chem Res Toxicol. 2009. PMID: 19166333 Review.

6

Managing the challenge of chemically reactive metabolites in drug development.

Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, Vermeulen N, Williams DP, Wilson ID, Baillie TA. Park BK, et al. Among authors: smith da. Nat Rev Drug Discov. 2011 Apr;10(4):292-306. doi: 10.1038/nrd3408. Nat Rev Drug Discov. 2011. PMID: 21455238 Review.

7

Evolution of ADME science: where else can modeling and simulation contribute?

Smith DA. Smith DA. Mol Pharm. 2013 Apr 1;10(4):1162-70. doi: 10.1021/mp3005319. Epub 2013 Jan 22. Mol Pharm. 2013. PMID: 23294153 Review.

8

Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?

Obach RS, Nedderman AN, Smith DA. Obach RS, et al. Among authors: smith da. Xenobiotica. 2012 Jan;42(1):46-56. doi: 10.3109/00498254.2011.621985. Epub 2011 Oct 12. Xenobiotica. 2012. PMID: 21992031 Review.

9

Which metabolites circulate?

Loi CM, Smith DA, Dalvie D. Loi CM, et al. Among authors: smith da. Drug Metab Dispos. 2013 May;41(5):933-51. doi: 10.1124/dmd.112.050278. Epub 2013 Mar 1. Drug Metab Dispos. 2013. PMID: 23454828

10

Metabolites: have we MIST out the importance of structure and physicochemistry?

Smith DA, Obach RS. Smith DA, et al. Bioanalysis. 2010 Jul;2(7):1223-33. doi: 10.4155/bio.10.92. Bioanalysis. 2010. PMID: 21083236 Review.

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