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Why do metabolites circulate?
Smith DA, Dalvie D. Smith DA, et al. Xenobiotica. 2012 Jan;42(1):107-26. doi: 10.3109/00498254.2011.630110. Epub 2011 Nov 24. Xenobiotica. 2012. PMID: 22115420 Review.
Managing the challenge of chemically reactive metabolites in drug development.
Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, Vermeulen N, Williams DP, Wilson ID, Baillie TA. Park BK, et al. Among authors: smith da. Nat Rev Drug Discov. 2011 Apr;10(4):292-306. doi: 10.1038/nrd3408. Nat Rev Drug Discov. 2011. PMID: 21455238 Review.
Which metabolites circulate?
Loi CM, Smith DA, Dalvie D. Loi CM, et al. Among authors: smith da. Drug Metab Dispos. 2013 May;41(5):933-51. doi: 10.1124/dmd.112.050278. Epub 2013 Mar 1. Drug Metab Dispos. 2013. PMID: 23454828
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