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Page 1
A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response.
Leibel SL, McVicar RN, Murad R, Kwong EM, Clark AE, Alvarado A, Grimmig BA, Nuryyev R, Young RE, Lee JC, Peng W, Zhu YP, Griffis E, Nowell CJ, James B, Alarcon S, Malhotra A, Gearing LJ, Hertzog PJ, Galapate CM, Galenkamp KMO, Commisso C, Smith DM, Sun X, Carlin AF, Sidman RL, Croker BA, Snyder EY. Leibel SL, et al. Among authors: smith dm. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2408109121. doi: 10.1073/pnas.2408109121. Epub 2024 Jul 19. Proc Natl Acad Sci U S A. 2024. PMID: 39028694 Free PMC article.
The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense.
Leibel SL, McVicar RN, Murad R, Kwong EM, Clark AE, Alvarado A, Grimmig BA, Nuryyev R, Young RE, Lee JC, Peng W, Zhu YP, Griffis E, Nowell CJ, Liu K, James B, Alarcon S, Malhotra A, Gearing LJ, Hertzog PJ, Galapate CM, Galenkamp KMO, Commisso C, Smith DM, Sun X, Carlin AF, Croker BA, Snyder EY. Leibel SL, et al. Among authors: smith dm. bioRxiv [Preprint]. 2023 Jan 27:2023.01.26.525578. doi: 10.1101/2023.01.26.525578. bioRxiv. 2023. PMID: 36747824 Free PMC article. Preprint.
Bamlanivimab therapy for acute COVID-19 does not blunt SARS-CoV-2-specific memory T cell responses.
Ramirez SI, Grifoni A, Weiskopf D, Parikh UM, Heaps A, Faraji F, Sieg SF, Ritz J, Moser C, Eron JJ, Currier JS, Klekotka P, Sette A, Wohl DA, Daar ES, Hughes MD, Chew KW, Smith DM, Crotty S; Accelerating COVID-19 Therapeutic Interventions and Vaccines–2/A5401 (ACTIV-2/A5401) Study Team. Ramirez SI, et al. Among authors: smith dm. JCI Insight. 2022 Dec 22;7(24):e163471. doi: 10.1172/jci.insight.163471. JCI Insight. 2022. PMID: 36378539 Free PMC article.
Variant-Specific Viral Kinetics in Acute COVID-19.
Ribeiro RM, Choudhary MC, Deo R, Giganti MJ, Moser C, Ritz J, Greninger AL, Regan J, Flynn JP, Wohl DA, Currier JS, Eron JJ, Hughes MD, Smith DM, Chew KW, Daar ES, Perelson AS, Li JZ; ACTIV-2/A5401 Study Team. Ribeiro RM, et al. Among authors: smith dm. J Infect Dis. 2023 Aug 31;228(Suppl 2):S136-S143. doi: 10.1093/infdis/jiad314. J Infect Dis. 2023. PMID: 37650233 Free PMC article. Clinical Trial.
Statistical Challenges When Analyzing SARS-CoV-2 RNA Measurements Below the Assay Limit of Quantification in COVID-19 Clinical Trials.
Moser CB, Chew KW, Giganti MJ, Li JZ, Aga E, Ritz J, Greninger AL, Javan AC, Bender Ignacio R, Daar ES, Wohl DA, Currier JS, Eron JJ, Smith DM, Hughes MD; ACTIV-2/A5401 Study Team. Moser CB, et al. Among authors: smith dm. J Infect Dis. 2023 Aug 31;228(Suppl 2):S101-S110. doi: 10.1093/infdis/jiad285. J Infect Dis. 2023. PMID: 37650235 Free PMC article. Clinical Trial.
Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody.
Phan T, Zitzmann C, Chew KW, Smith DM, Daar ES, Wohl DA, Eron JJ, Currier JS, Hughes MD, Choudhary MC, Deo R, Li JZ, Ribeiro RM, Ke R, Perelson AS; ACTIV-2/A5401 Study Team. Phan T, et al. Among authors: smith dm. PLoS Pathog. 2024 Apr 18;20(4):e1011680. doi: 10.1371/journal.ppat.1011680. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38635853 Free PMC article.
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schäfer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R. Zhou P, et al. Among authors: smith dm. Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005. Epub 2023 Feb 16. Immunity. 2023. PMID: 36889306 Free PMC article.
Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody.
Phan T, Zitzmann C, Chew KW, Smith DM, Daar ES, Wohl DA, Eron JJ, Currier JS, Hughes MD, Choudhary MC, Deo R, Li JZ, Ribeiro RM, Ke R, Perelson AS; ACTIV-2/A5401 Study Team. Phan T, et al. Among authors: smith dm. bioRxiv [Preprint]. 2023 Sep 17:2023.09.14.557679. doi: 10.1101/2023.09.14.557679. bioRxiv. 2023. Update in: PLoS Pathog. 2024 Apr 18;20(4):e1011680. doi: 10.1371/journal.ppat.1011680 PMID: 37745410 Free PMC article. Updated. Preprint.
SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback.
Coelho CH, Bloom N, Ramirez SI, Parikh UM, Heaps A, Sieg SF, Greninger A, Ritz J, Moser C, Eron JJ, Currier JS, Klekotka P, Wohl DA, Daar ES, Li J, Hughes MD, Chew KW, Smith DM, Crotty S; Accelerating COVID-19 Therapeutic Interventions and Vaccines–2/A5401 (ACTIV-2/A5401) Study Team. Coelho CH, et al. Among authors: smith dm. bioRxiv [Preprint]. 2023 Nov 22:2023.11.21.567575. doi: 10.1101/2023.11.21.567575. bioRxiv. 2023. Update in: J Infect Dis. 2024 Nov 15;230(5):1187-1196. doi: 10.1093/infdis/jiae371 PMID: 38045374 Free PMC article. Updated. Preprint.
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection.
Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF, Wilson IA, Burton DR, Andrabi R. Zhou P, et al. Among authors: smith dm. bioRxiv [Preprint]. 2022 Jan 21:2021.03.30.437769. doi: 10.1101/2021.03.30.437769. bioRxiv. 2022. Update in: Sci Transl Med. 2022 Mar 23;14(637):eabi9215. doi: 10.1126/scitranslmed.abi9215 PMID: 33821273 Free PMC article. Updated. Preprint.
1,863 results