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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, Rajendra E, Ranzani M, Schaedler T, Stockley M, Wiggins K, Brough R, Sridhar S, Gulati A, Shao N, Badder LM, Novo D, Knight EG, Marlow R, Haider S, Callen E, Hewitt G, Schimmel J, Prevo R, Alli C, Ferdinand A, Bell C, Blencowe P, Bot C, Calder M, Charles M, Curry J, Ekwuru T, Ewings K, Krajewski W, MacDonald E, McCarron H, Pang L, Pedder C, Rigoreau L, Swarbrick M, Wheatley E, Willis S, Wong AC, Nussenzweig A, Tijsterman M, Tutt A, Boulton SJ, Higgins GS, Pettitt SJ, Smith GCM, Lord CJ. Zatreanu D, et al. Among authors: smith gcm. Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8. Nat Commun. 2021. PMID: 34140467
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
He W, McCarroll CS, Nather K, Ford K, Mangion K, Riddell A, O'Toole D, Zaeri A, Corcoran D, Carrick D, Lee MMY, McEntegart M, Davie A, Good R, Lindsay MM, Eteiba H, Rocchiccioli P, Watkins S, Hood S, Shaukat A, McArthur L, Elliott EB, McClure J, Hawksby C, Martin T, Petrie MC, Oldroyd KG, Smith GL; Oxford Acute Myocardial Infarction (OxAMI) Study, Channon KM, Berry C, Nicklin SA, Loughrey CM. He W, et al. Among authors: smith gl. Cardiovasc Res. 2021 Jun 16:cvab204. doi: 10.1093/cvr/cvab204. Online ahead of print. Cardiovasc Res. 2021. PMID: 34132807
Chemotherapy Versus Chemotherapy Plus Chemoradiation as Neoadjuvant Therapy for Resectable Gastric Adenocarcinoma: A Multi-Institutional Analysis.
Allen CJ, Pointer DT Jr, Blumenthaler AN, Mehta RJ, Hoffe SE, Minsky BD, Smith GL, Blum M, Mansfield PF, Ikoma N, Das P, Ajani J, Dineen SP, Fleming JB, Badgwell BD, Pimiento JM. Allen CJ, et al. Among authors: smith gl. Ann Surg. 2021 Jun 16. doi: 10.1097/SLA.0000000000005007. Online ahead of print. Ann Surg. 2021. PMID: 34132693
The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis.
Barron-Millar B, Ogle L, Mells G, Flack S, Badrock J, Sandford R, Kirby J, Palmer J, Jopson L, Brain J, Smith GR, Rushton S, Hegade VS, Jones R, Rushbrook S, Thorburn D, Ryder S, Hirschfield G; UK-PBC Research Consortium, Dyson JK, Jones D. Barron-Millar B, et al. Among authors: smith gr. Hepatology. 2021 Jun 15. doi: 10.1002/hep.32011. Online ahead of print. Hepatology. 2021. PMID: 34129689
Correction to: Acute hyperglycaemia does not have a consistent adverse effect on exercise performance in recreationally active young people with type 1 diabetes: a randomised crossover in-clinic study.
Rothacker KM, Armstrong S, Smith GJ, Benjanuvatra N, Lay B, Adolfsson P, Jones TW, Fournier PA, Davis EA. Rothacker KM, et al. Among authors: smith gj. Diabetologia. 2021 Jun 11. doi: 10.1007/s00125-021-05486-4. Online ahead of print. Diabetologia. 2021. PMID: 34115148 No abstract available.
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