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1,003 results
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A. Farmer H, et al. Among authors: smith gc. Nature. 2005 Apr 14;434(7035):917-21. doi: 10.1038/nature03445. Nature. 2005. PMID: 15829967
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.
Evers B, Drost R, Schut E, de Bruin M, van der Burg E, Derksen PW, Holstege H, Liu X, van Drunen E, Beverloo HB, Smith GC, Martin NM, Lau A, O'Connor MJ, Jonkers J. Evers B, et al. Among authors: smith gc. Clin Cancer Res. 2008 Jun 15;14(12):3916-25. doi: 10.1158/1078-0432.CCR-07-4953. Clin Cancer Res. 2008. PMID: 18559613
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP. Jazayeri A, et al. Among authors: smith gc. Nat Cell Biol. 2006 Jan;8(1):37-45. doi: 10.1038/ncb1337. Epub 2005 Dec 4. Nat Cell Biol. 2006. PMID: 16327781
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, Giavara S, O'Connor MJ, Tutt AN, Zdzienicka MZ, Smith GC, Ashworth A. McCabe N, et al. Among authors: smith gc. Cancer Res. 2006 Aug 15;66(16):8109-15. doi: 10.1158/0008-5472.CAN-06-0140. Cancer Res. 2006. PMID: 16912188
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.
Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW. Veuger SJ, et al. Among authors: smith gc. Cancer Res. 2003 Sep 15;63(18):6008-15. Cancer Res. 2003. PMID: 14522929
Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation.
Mitchell J, Smith GC, Curtin NJ. Mitchell J, et al. Among authors: smith gc. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. doi: 10.1016/j.ijrobp.2009.07.1722. Int J Radiat Oncol Biol Phys. 2009. PMID: 19931734
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.
Lau A, Swinbank KM, Ahmed PS, Taylor DL, Jackson SP, Smith GC, O'Connor MJ. Lau A, et al. Among authors: smith gc. Nat Cell Biol. 2005 May;7(5):493-500. doi: 10.1038/ncb1250. Epub 2005 Apr 17. Nat Cell Biol. 2005. PMID: 15834407
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.
Menear KA, Adcock C, Boulter R, Cockcroft XL, Copsey L, Cranston A, Dillon KJ, Drzewiecki J, Garman S, Gomez S, Javaid H, Kerrigan F, Knights C, Lau A, Loh VM Jr, Matthews IT, Moore S, O'Connor MJ, Smith GC, Martin NM. Menear KA, et al. Among authors: smith gc. J Med Chem. 2008 Oct 23;51(20):6581-91. doi: 10.1021/jm8001263. Epub 2008 Sep 19. J Med Chem. 2008. PMID: 18800822
Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase.
Menear KA, Adcock C, Alonso FC, Blackburn K, Copsey L, Drzewiecki J, Fundo A, Le Gall A, Gomez S, Javaid H, Lence CF, Martin NM, Mydlowski C, Smith GC. Menear KA, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3942-5. doi: 10.1016/j.bmcl.2008.06.025. Epub 2008 Jun 12. Bioorg Med Chem Lett. 2008. PMID: 18579376
Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase.
Cockcroft XL, Dillon KJ, Dixon L, Drzewiecki J, Kerrigan F, Loh VM Jr, Martin NM, Menear KA, Smith GC. Cockcroft XL, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2006 Feb 15;16(4):1040-4. doi: 10.1016/j.bmcl.2005.10.081. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16290932
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