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Page 1
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
Hoffman RL, Kania RS, Brothers MA, Davies JF, Ferre RA, Gajiwala KS, He M, Hogan RJ, Kozminski K, Li LY, Lockner JW, Lou J, Marra MT, Mitchell LJ Jr, Murray BW, Nieman JA, Noell S, Planken SP, Rowe T, Ryan K, Smith GJ 3rd, Solowiej JE, Steppan CM, Taggart B. Hoffman RL, et al. Among authors: smith gj 3rd. J Med Chem. 2020 Nov 12;63(21):12725-12747. doi: 10.1021/acs.jmedchem.0c01063. Epub 2020 Oct 15. J Med Chem. 2020. PMID: 33054210
Anti-interleukin-10R1 monoclonal antibody enhances bacillus Calmette-Guérin induced T-helper type 1 immune responses and antitumor immunity in a mouse orthotopic model of bladder cancer.
Bockholt NA, Knudson MJ, Henning JR, Maymí JL, Weady P, Smith GJ 3rd, Eisenbraun MD, Fraser JD, O'Donnell MA, Luo Y. Bockholt NA, et al. Among authors: smith gj 3rd. J Urol. 2012 Jun;187(6):2228-35. doi: 10.1016/j.juro.2012.01.030. Epub 2012 Apr 13. J Urol. 2012. PMID: 22503050
In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease.
Patick AK, Brothers MA, Maldonado F, Binford S, Maldonado O, Fuhrman S, Petersen A, Smith GJ 3rd, Zalman LS, Burns-Naas LA, Tran JQ. Patick AK, et al. Among authors: smith gj 3rd. Antimicrob Agents Chemother. 2005 Jun;49(6):2267-75. doi: 10.1128/AAC.49.6.2267-2275.2005. Antimicrob Agents Chemother. 2005. PMID: 15917520 Free PMC article. Clinical Trial.
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.
Hayden FG, Turner RB, Gwaltney JM, Chi-Burris K, Gersten M, Hsyu P, Patick AK, Smith GJ 3rd, Zalman LS. Hayden FG, et al. Among authors: smith gj 3rd. Antimicrob Agents Chemother. 2003 Dec;47(12):3907-16. doi: 10.1128/AAC.47.12.3907-3916.2003. Antimicrob Agents Chemother. 2003. PMID: 14638501 Free PMC article. Clinical Trial.