Smith JD - Search Results

1

4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.

Leeson PD, Carling RW, Moore KW, Moseley AM, Smith JD, Stevenson G, Chan T, Baker R, Foster AC, Grimwood S, et al. Leeson PD, et al. Among authors: smith jd. J Med Chem. 1992 May 29;35(11):1954-68. doi: 10.1021/jm00089a004. J Med Chem. 1992. PMID: 1534584

2

Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.

Foster AC, Kemp JA, Leeson PD, Grimwood S, Donald AE, Marshall GR, Priestley T, Smith JD, Carling RW. Foster AC, et al. Among authors: smith jd. Mol Pharmacol. 1992 May;41(5):914-22. Mol Pharmacol. 1992. PMID: 1375317

3

Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel.

Leeson PD, Carling RW, James K, Smith JD, Moore KW, Wong EH, Baker R. Leeson PD, et al. Among authors: smith jd. J Med Chem. 1990 May;33(5):1296-305. doi: 10.1021/jm00167a005. J Med Chem. 1990. PMID: 1691788

4

3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

Carling RW, Leeson PD, Moore KW, Smith JD, Moyes CR, Mawer IM, Thomas S, Chan T, Baker R, Foster AC, et al. Carling RW, et al. Among authors: smith jd. J Med Chem. 1993 Oct 29;36(22):3397-408. doi: 10.1021/jm00074a021. J Med Chem. 1993. PMID: 8230130

5

Identification and exploitation of the sigma-opiate pharmacophore.

Glennon RA, Smith JD, Ismaiel AM, el-Ashmawy M, Battaglia G, Fischer JB. Glennon RA, et al. Among authors: smith jd. J Med Chem. 1991 Mar;34(3):1094-8. doi: 10.1021/jm00107a033. J Med Chem. 1991. PMID: 1848295

6

N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites?

Glennon RA, Naiman NA, Pierson ME, Smith JD, Ismaiel AM, Titeler M, Lyon RA. Glennon RA, et al. Among authors: smith jd. J Med Chem. 1989 Aug;32(8):1921-6. doi: 10.1021/jm00128a039. J Med Chem. 1989. PMID: 2754715

7

Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors.

Glennon RA, Ismaiel AM, Smith JD, Yousif M, el-Ashmawy M, Herndon JL, Fischer JB, Howie KJ, Server AC. Glennon RA, et al. Among authors: smith jd. J Med Chem. 1991 Jun;34(6):1855-9. doi: 10.1021/jm00110a015. J Med Chem. 1991. PMID: 1648139

8

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.

Liang J, Van Abbema A, Balazs M, Barrett K, Berezhkovsky L, Blair WS, Chang C, Delarosa D, DeVoss J, Driscoll J, Eigenbrot C, Goodacre S, Ghilardi N, MacLeod C, Johnson A, Bir Kohli P, Lai Y, Lin Z, Mantik P, Menghrajani K, Nguyen H, Peng I, Sambrone A, Shia S, Smith J, Sohn S, Tsui V, Ultsch M, Williams K, Wu LC, Yang W, Zhang B, Magnuson S. Liang J, et al. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4370-4376. doi: 10.1016/j.bmcl.2017.08.022. Epub 2017 Aug 12. Bioorg Med Chem Lett. 2017. PMID: 28830649

9

Lead identification of novel and selective TYK2 inhibitors.

Liang J, Tsui V, Van Abbema A, Bao L, Barrett K, Beresini M, Berezhkovskiy L, Blair WS, Chang C, Driscoll J, Eigenbrot C, Ghilardi N, Gibbons P, Halladay J, Johnson A, Kohli PB, Lai Y, Liimatta M, Mantik P, Menghrajani K, Murray J, Sambrone A, Xiao Y, Shia S, Shin Y, Smith J, Sohn S, Stanley M, Ultsch M, Zhang B, Wu LC, Magnuson S. Liang J, et al. Eur J Med Chem. 2013 Sep;67:175-87. doi: 10.1016/j.ejmech.2013.03.070. Epub 2013 May 14. Eur J Med Chem. 2013. PMID: 23867602

10

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.

Liang J, van Abbema A, Balazs M, Barrett K, Berezhkovsky L, Blair W, Chang C, Delarosa D, DeVoss J, Driscoll J, Eigenbrot C, Ghilardi N, Gibbons P, Halladay J, Johnson A, Kohli PB, Lai Y, Liu Y, Lyssikatos J, Mantik P, Menghrajani K, Murray J, Peng I, Sambrone A, Shia S, Shin Y, Smith J, Sohn S, Tsui V, Ultsch M, Wu LC, Xiao Y, Yang W, Young J, Zhang B, Zhu BY, Magnuson S. Liang J, et al. J Med Chem. 2013 Jun 13;56(11):4521-36. doi: 10.1021/jm400266t. Epub 2013 May 29. J Med Chem. 2013. PMID: 23668484

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