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1,435 results
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NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
Smith MJ, Neel BG, Ikura M. Smith MJ, et al. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4574-9. doi: 10.1073/pnas.1218173110. Epub 2013 Mar 4. Proc Natl Acad Sci U S A. 2013. PMID: 23487764 Free PMC article.
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1.
Smith MJ, Hardy WR, Li GY, Goudreault M, Hersch S, Metalnikov P, Starostine A, Pawson T, Ikura M. Smith MJ, et al. EMBO J. 2010 Mar 3;29(5):884-96. doi: 10.1038/emboj.2009.399. Epub 2010 Jan 14. EMBO J. 2010. PMID: 20075861 Free PMC article.
Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).
Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith MJ, Nishikawa T, Xu Y, Neel BG, Ikura M. Fang Z, et al. J Biol Chem. 2016 Jul 22;291(30):15641-52. doi: 10.1074/jbc.M116.714196. Epub 2016 May 18. J Biol Chem. 2016. PMID: 27226556 Free PMC article.
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Mazhab-Jafari MT, Marshall CB, Smith MJ, Gasmi-Seabrook GM, Stathopulos PB, Inagaki F, Kay LE, Neel BG, Ikura M. Mazhab-Jafari MT, et al. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6625-30. doi: 10.1073/pnas.1419895112. Epub 2015 May 4. Proc Natl Acad Sci U S A. 2015. PMID: 25941399 Free PMC article.
Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.
Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M. Marshall CB, et al. Methods. 2012 Aug;57(4):473-85. doi: 10.1016/j.ymeth.2012.06.014. Epub 2012 Jun 28. Methods. 2012. PMID: 22750304
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T. Findlay GM, et al. Cell. 2013 Feb 28;152(5):1008-20. doi: 10.1016/j.cell.2013.01.056. Cell. 2013. PMID: 23452850
Real-time NMR monitoring of biological activities in complex physiological environments.
Smith MJ, Marshall CB, Theillet FX, Binolfi A, Selenko P, Ikura M. Smith MJ, et al. Curr Opin Struct Biol. 2015 Jun;32:39-47. doi: 10.1016/ Epub 2015 Feb 27. Curr Opin Struct Biol. 2015. PMID: 25727665 Review.
A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues.
Long D, Marshall CB, Bouvignies G, Mazhab-Jafari MT, Smith MJ, Ikura M, Kay LE. Long D, et al. Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10771-4. doi: 10.1002/anie.201305434. Epub 2013 Aug 22. Angew Chem Int Ed Engl. 2013. PMID: 24039022 No abstract available.
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