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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1982 1
1985 3
1986 1
1987 1
1988 2
1989 1
1990 1
1992 4
1993 3
1994 2
1995 2
1996 4
1997 1
1998 1
1999 1
2000 4
2001 3
2002 3
2003 3
2004 4
2005 5
2006 2
2007 2
2009 3
2010 3
2011 2
2012 2
2013 2
2014 2
2015 5
2016 2
2017 1
2018 1
2020 2
2023 0

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79 results

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Page 1
The classical complement cascade mediates CNS synapse elimination.
Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B, Sher A, Litke AM, Lambris JD, Smith SJ, John SW, Barres BA. Stevens B, et al. Among authors: smith sj. Cell. 2007 Dec 14;131(6):1164-78. doi: 10.1016/j.cell.2007.10.036. Cell. 2007. PMID: 18083105 Free article.
Here we show that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response to immature astrocytes and is localized to synapses throughout the postnatal CNS and retina. Mice deficient in complement protein C1q or the dow …
Here we show that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response to immature …
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways.
Chung WS, Clarke LE, Wang GX, Stafford BK, Sher A, Chakraborty C, Joung J, Foo LC, Thompson A, Chen C, Smith SJ, Barres BA. Chung WS, et al. Among authors: smith sj. Nature. 2013 Dec 19;504(7480):394-400. doi: 10.1038/nature12776. Epub 2013 Nov 24. Nature. 2013. PMID: 24270812 Free PMC article.
Here we report a new role for astrocytes in actively engulfing central nervous system synapses. This process helps to mediate synapse elimination, requires the MEGF10 and MERTK phagocytic pathways, and is strongly dependent on neuronal activity. Developing mice defi …
Here we report a new role for astrocytes in actively engulfing central nervous system synapses. This process helps to mediate syna …
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
Paşca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O'Rourke NA, Nguyen KD, Smith SJ, Huguenard JR, Geschwind DH, Barres BA, Paşca SP. Paşca AM, et al. Among authors: smith sj. Nat Methods. 2015 Jul;12(7):671-8. doi: 10.1038/nmeth.3415. Epub 2015 May 25. Nat Methods. 2015. PMID: 26005811 Free PMC article.
These neurons are electrophysiologically mature, display spontaneous activity, are surrounded by nonreactive astrocytes and form functional synapses. Experiments in acute hCS slices demonstrate that cortical neurons participate in network activity and produce complex synap …
These neurons are electrophysiologically mature, display spontaneous activity, are surrounded by nonreactive astrocytes and form functional …
New light on cortical neuropeptides and synaptic network plasticity.
Smith SJ, Hawrylycz M, Rossier J, Sümbül U. Smith SJ, et al. Curr Opin Neurobiol. 2020 Aug;63:176-188. doi: 10.1016/j.conb.2020.04.002. Epub 2020 Jul 14. Curr Opin Neurobiol. 2020. PMID: 32679509 Free article. Review.
At the cellular level, neuropeptides are known to act mainly via modulation of ion channel and synapse function, but functional impacts emerging at the level of complex cortical synaptic networks have resisted mechanistic analysis. ...
At the cellular level, neuropeptides are known to act mainly via modulation of ion channel and synapse function, but functional impac …
Probabilistic fluorescence-based synapse detection.
Simhal AK, Aguerrebere C, Collman F, Vogelstein JT, Micheva KD, Weinberg RJ, Smith SJ, Sapiro G. Simhal AK, et al. Among authors: smith sj. PLoS Comput Biol. 2017 Apr 17;13(4):e1005493. doi: 10.1371/journal.pcbi.1005493. eCollection 2017 Apr. PLoS Comput Biol. 2017. PMID: 28414801 Free PMC article.
Deeper exploration of the brain's vast synaptic networks will require new tools for high-throughput structural and molecular profiling of the diverse populations of synapses that compose those networks. ...To develop and test single-synapse image analysis met …
Deeper exploration of the brain's vast synaptic networks will require new tools for high-throughput structural and molecular profilin …
Circuit reconstruction tools today.
Smith SJ. Smith SJ. Curr Opin Neurobiol. 2007 Oct;17(5):601-8. doi: 10.1016/j.conb.2007.11.004. Epub 2007 Dec 21. Curr Opin Neurobiol. 2007. PMID: 18082394 Free PMC article. Review.
To understand how a brain processes information, we must understand the structure of its neural circuits-especially circuit interconnection topologies and the cell and synapse molecular architectures that determine circuit-signaling dynamics. ...
To understand how a brain processes information, we must understand the structure of its neural circuits-especially circuit interconnection …
A synapse census for the ages.
Micheva KD, Weinberg RJ, Smith SJ. Micheva KD, et al. Among authors: smith sj. Science. 2020 Jul 17;369(6501):253-254. doi: 10.1126/science.abc9555. Science. 2020. PMID: 32675362 Free PMC article. No abstract available.
Deep molecular diversity of mammalian synapses: why it matters and how to measure it.
O'Rourke NA, Weiler NC, Micheva KD, Smith SJ. O'Rourke NA, et al. Among authors: smith sj. Nat Rev Neurosci. 2012 May 10;13(6):365-79. doi: 10.1038/nrn3170. Nat Rev Neurosci. 2012. PMID: 22573027 Free PMC article. Review.
Pioneering studies in the middle of the twentieth century revealed substantial diversity among mammalian chemical synapses and led to a widely accepted classification of synapse type on the basis of neurotransmitter molecule identity. ...Today, this deep diversity c …
Pioneering studies in the middle of the twentieth century revealed substantial diversity among mammalian chemical synapses and led to …
Large-scale automated histology in the pursuit of connectomes.
Kleinfeld D, Bharioke A, Blinder P, Bock DD, Briggman KL, Chklovskii DB, Denk W, Helmstaedter M, Kaufhold JP, Lee WC, Meyer HS, Micheva KD, Oberlaender M, Prohaska S, Reid RC, Smith SJ, Takemura S, Tsai PS, Sakmann B. Kleinfeld D, et al. Among authors: smith sj. J Neurosci. 2011 Nov 9;31(45):16125-38. doi: 10.1523/JNEUROSCI.4077-11.2011. J Neurosci. 2011. PMID: 22072665 Free PMC article. Review.
Answering this question necessitates neuronal connectomes, annotated graphs of all synaptic connections within defined brain areas. Further, understanding the energetics of the brain's computations requires vascular graphs. The assembly of a connectome requires sensitive h …
Answering this question necessitates neuronal connectomes, annotated graphs of all synaptic connections within defined brain areas. Further, …
Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers.
Micheva KD, Busse B, Weiler NC, O'Rourke N, Smith SJ. Micheva KD, et al. Among authors: smith sj. Neuron. 2010 Nov 18;68(4):639-53. doi: 10.1016/j.neuron.2010.09.024. Neuron. 2010. PMID: 21092855 Free PMC article.
A lack of methods for measuring the protein compositions of individual synapses in situ has so far hindered the exploration and exploitation of synapse molecular diversity. ...We find that virtually all synapses are recognized by antibodies to the presynaptic …
A lack of methods for measuring the protein compositions of individual synapses in situ has so far hindered the exploration and explo …
79 results