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Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by beta-catenin.
van Gijn ME, Snel F, Cleutjens JP, Smits JF, Blankesteijn WM. van Gijn ME, et al. Among authors: smits jf. Exp Cell Res. 2001 Apr 15;265(1):46-53. doi: 10.1006/excr.2001.5174. Exp Cell Res. 2001. PMID: 11281642
Long-term structural and functional consequences of cardiac ischaemia-reperfusion injury in vivo in mice.
De Celle T, Cleutjens JP, Blankesteijn WM, Debets JJ, Smits JF, Janssen BJ. De Celle T, et al. Among authors: smits jf. Exp Physiol. 2004 Sep;89(5):605-15. doi: 10.1113/expphysiol.2004.027649. Epub 2004 Jul 15. Exp Physiol. 2004. PMID: 15258119
N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts.
Pokharel S, Rasoul S, Roks AJ, van Leeuwen RE, van Luyn MJ, Deelman LE, Smits JF, Carretero O, van Gilst WH, Pinto YM. Pokharel S, et al. Among authors: smits jf. Hypertension. 2002 Aug;40(2):155-61. doi: 10.1161/01.hyp.0000025880.56816.fa. Hypertension. 2002. PMID: 12154106
Changes in vascular distensibility during angiotensin-converting enzyme inhibition involve bradykinin type 2 receptors.
Aartsen WM, Hilgers RH, Schiffers PM, Daemen MJ, De Mey JG, Smits JF. Aartsen WM, et al. Among authors: smits jf. J Vasc Res. 2004 Jan-Feb;41(1):18-27. doi: 10.1159/000076125. Epub 2004 Jan 12. J Vasc Res. 2004. PMID: 14726629
The Wnt/Frizzled pathway as a therapeutic target for cardiac hypertrophy: where do we stand?
ter Horst P, Smits JF, Blankesteijn WM. ter Horst P, et al. Among authors: smits jf. Acta Physiol (Oxf). 2012 Jan;204(1):110-7. doi: 10.1111/j.1748-1716.2011.02309.x. Epub 2011 May 27. Acta Physiol (Oxf). 2012. PMID: 21624093 Review.
G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors.
Verkaar F, van Rosmalen JW, Blomenröhr M, van Koppen CJ, Blankesteijn WM, Smits JF, Zaman GJ. Verkaar F, et al. Among authors: smits jf. Biotechnol Annu Rev. 2008;14:253-74. doi: 10.1016/S1387-2656(08)00010-0. Biotechnol Annu Rev. 2008. PMID: 18606367 Review.
Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.
Verkaar F, van Rosmalen JW, Smits JF, Blankesteijn WM, Zaman GJ. Verkaar F, et al. Among authors: smits jf. Cell Signal. 2009 Jan;21(1):22-33. doi: 10.1016/j.cellsig.2008.09.008. Epub 2008 Sep 25. Cell Signal. 2009. PMID: 18929644
beta-Galactosidase enzyme fragment complementation for the measurement of Wnt/beta-catenin signaling.
Verkaar F, Blankesteijn WM, Smits JF, Zaman GJ. Verkaar F, et al. Among authors: smits jf. FASEB J. 2010 Apr;24(4):1205-17. doi: 10.1096/fj.09-141671. Epub 2009 Nov 25. FASEB J. 2010. PMID: 19940259
The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.
Blankesteijn WM, van de Schans VA, ter Horst P, Smits JF. Blankesteijn WM, et al. Among authors: smits jf. Trends Pharmacol Sci. 2008 Apr;29(4):175-80. doi: 10.1016/j.tips.2008.01.003. Epub 2008 Mar 14. Trends Pharmacol Sci. 2008. PMID: 18342376 Review.
The Wnt/frizzled pathway in cardiovascular development and disease: friend or foe?
van de Schans VA, Smits JF, Blankesteijn WM. van de Schans VA, et al. Among authors: smits jf. Eur J Pharmacol. 2008 May 13;585(2-3):338-45. doi: 10.1016/j.ejphar.2008.02.093. Epub 2008 Mar 18. Eur J Pharmacol. 2008. PMID: 18417121 Review.
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