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Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.
Smits R, Kartheuser A, Jagmohan-Changur S, Leblanc V, Breukel C, de Vries A, van Kranen H, van Krieken JH, Williamson S, Edelmann W, Kucherlapati R, KhanPM, Fodde R. Smits R, et al. Carcinogenesis. 1997 Feb;18(2):321-7. doi: 10.1093/carcin/18.2.321. Carcinogenesis. 1997. PMID: 9054624
The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model.
van der Houven van Oordt CW, Smits R, Schouten TG, Houwing-Duistermaat JJ, Williamson SL, Luz A, Meera Khan P, van der Eb AJ, Breuer ML, Fodde R. van der Houven van Oordt CW, et al. Among authors: smits r. Genes Chromosomes Cancer. 1999 Mar;24(3):191-8. doi: 10.1002/(sici)1098-2264(199903)24:3<191::aid-gcc3>;2-l. Genes Chromosomes Cancer. 1999. PMID: 10451698
252 results