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Mechanisms of ATR-mediated checkpoint signalling.
Smits VA, Warmerdam DO, Martin Y, Freire R. Smits VA, et al. Front Biosci (Landmark Ed). 2010 Jun 1;15:840-53. doi: 10.2741/3649. Front Biosci (Landmark Ed). 2010. PMID: 20515729 Review.
p21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint.
Smits VA, Klompmaker R, Vallenius T, Rijksen G, Mäkela TP, Medema RH. Smits VA, et al. J Biol Chem. 2000 Sep 29;275(39):30638-43. doi: 10.1074/jbc.M005437200. J Biol Chem. 2000. PMID: 10913154
Polo-like kinase-1 is a target of the DNA damage checkpoint.
Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, Medema RH. Smits VA, et al. Nat Cell Biol. 2000 Sep;2(9):672-6. doi: 10.1038/35023629. Nat Cell Biol. 2000. PMID: 10980711
Spreading the signal: dissociation of Chk1 from chromatin.
Smits VA. Smits VA. Cell Cycle. 2006 May;5(10):1039-43. doi: 10.4161/cc.5.10.2761. Epub 2006 May 15. Cell Cycle. 2006. PMID: 16721053
Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome.
Semple JI, Smits VA, Fernaud JR, Mamely I, Freire R. Semple JI, et al. Cell Death Differ. 2007 Aug;14(8):1433-42. doi: 10.1038/sj.cdd.4402134. Epub 2007 Apr 13. Cell Death Differ. 2007. PMID: 17431426
ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage.
Medhurst AL, Warmerdam DO, Akerman I, Verwayen EH, Kanaar R, Smits VA, Lakin ND. Medhurst AL, et al. J Cell Sci. 2008 Dec 1;121(Pt 23):3933-40. doi: 10.1242/jcs.033688. J Cell Sci. 2008. PMID: 19020305
Differential Dynamics of ATR-Mediated Checkpoint Regulators.
Warmerdam DO, Kanaar R, Smits VA. Warmerdam DO, et al. J Nucleic Acids. 2010 Aug 17;2010:319142. doi: 10.4061/2010/319142. J Nucleic Acids. 2010. PMID: 20847938 Free PMC article.
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