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Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.
Dumanski JP, Rasi C, Lönn M, Davies H, Ingelsson M, Giedraitis V, Lannfelt L, Magnusson PK, Lindgren CM, Morris AP, Cesarini D, Johannesson M, Tiensuu Janson E, Lind L, Pedersen NL, Ingelsson E, Forsberg LA. Dumanski JP, et al. Science. 2015 Jan 2;347(6217):81-3. doi: 10.1126/science.1262092. Epub 2014 Dec 4. Science. 2015. PMID: 25477213 Free PMC article.
Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. ...The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking indu …
Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. ...The d …
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.
Zink F, Stacey SN, Norddahl GL, Frigge ML, Magnusson OT, Jonsdottir I, Thorgeirsson TE, Sigurdsson A, Gudjonsson SA, Gudmundsson J, Jonasson JG, Tryggvadottir L, Jonsson T, Helgason A, Gylfason A, Sulem P, Rafnar T, Thorsteinsdottir U, Gudbjartsson DF, Masson G, Kong A, Stefansson K. Zink F, et al. Blood. 2017 Aug 10;130(6):742-752. doi: 10.1182/blood-2017-02-769869. Epub 2017 May 8. Blood. 2017. PMID: 28483762 Free PMC article.
We show that somatic mutations in TET2, DNMT3A, ASXL1, and PPM1D are associated with CH at high significance. However, known CD mutations were evident in only a fraction of CH cases. Nevertheless, the highly prevalent CH we detect associates with increased mortality …
We show that somatic mutations in TET2, DNMT3A, ASXL1, and PPM1D are associated with CH at high significance. However, known CD mutat …
Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease.
Dumanski JP, Lambert JC, Rasi C, Giedraitis V, Davies H, Grenier-Boley B, Lindgren CM, Campion D, Dufouil C; European Alzheimer’s Disease Initiative Investigators; Pasquier F, Amouyel P, Lannfelt L, Ingelsson M, Kilander L, Lind L, Forsberg LA. Dumanski JP, et al. Am J Hum Genet. 2016 Jun 2;98(6):1208-1219. doi: 10.1016/j.ajhg.2016.05.014. Epub 2016 May 23. Am J Hum Genet. 2016. PMID: 27231129 Free PMC article. Clinical Trial.
Our previous results show that a fundamentally different genetic variant, i.e., lifetime-acquired loss of chromosome Y (LOY) in blood cells, is associated with all-cause mortality and an increased risk of non-hematological tumors and that LOY could be …
Our previous results show that a fundamentally different genetic variant, i.e., lifetime-acquired loss of chromosome Y …
Y chromosome mosaicism is associated with age-related macular degeneration.
Grassmann F, Kiel C, den Hollander AI, Weeks DE, Lotery A, Cipriani V, Weber BHF; International Age-related Macular Degeneration Genomics Consortium (IAMDGC). Grassmann F, et al. Eur J Hum Genet. 2019 Jan;27(1):36-41. doi: 10.1038/s41431-018-0238-8. Epub 2018 Aug 29. Eur J Hum Genet. 2019. PMID: 30158665 Free PMC article.
Mosaic loss of Y chromosome (mLOY) in peripheral blood was estimated from normalised dosages of genotyping chip data covering the male-specific region of the Y chromosome. ...Additionally conditioning on smoking behaviour had no in …
Mosaic loss of Y chromosome (mLOY) in peripheral blood was estimated from normalised dosages of genotyping chip …
Mosaic loss of chromosome Y, tobacco smoking, and risk of age-related lung diseases: insights from two prospective cohorts.
Weng C, Zhao Y, Song M, Shao Z, Pang Y, Yu C, Pei P, Yang L, Millwood IY, Walters RG, Chen Y, Du H, Chen J, Chen Z, Genovese G, Terao C, Lv J, Li L, Sun D; China Kadoorie Biobank Collaborative Group. Weng C, et al. Eur Respir J. 2024 Oct 10:2400968. doi: 10.1183/13993003.00968-2024. Online ahead of print. Eur Respir J. 2024. PMID: 39401857 Free article.
BACKGROUND: Little is known about the underlying relationship between mosaic loss of chromosome Y (mLOY), the most common chromosomal alterations in older men, and the risk of age-related lung diseases. ...For current smokers carrying mLOY, adopting qu …
BACKGROUND: Little is known about the underlying relationship between mosaic loss of chromosome Y (mLOY), the mo …
Association of Mosaic Loss of Chromosome Y with Lung Cancer Risk and Prognosis in a Chinese Population.
Qin N, Li N, Wang C, Pu Z, Ma Z, Jin G, Zhu M, Dai M, Hu Z, Ma H, Shen H. Qin N, et al. J Thorac Oncol. 2019 Jan;14(1):37-44. doi: 10.1016/j.jtho.2018.09.013. Epub 2018 Sep 26. J Thorac Oncol. 2019. PMID: 30267841 Free article.
INTRODUCTION: Mosaic loss of chromosome Y (mLOY) is the most commonly detectable mosaic chromosomal event in cancers; however, its underlying relationship with tumorigenesis is still unclear. ...CONCLUSIONS: In summary, we propose a "two-sides" …
INTRODUCTION: Mosaic loss of chromosome Y (mLOY) is the most commonly detectable mosaic chromosomal event …
Genetic Predisposition to Mosaic Chromosomal Loss Is Associated With Functional Outcome After Ischemic Stroke.
Johansson M, Pedersen A, Cole JW, Lagging C, Lindgren A, Maguire JM, Rost NS, Söderholm M, Worrall BB, Stanne TM, Jern C. Johansson M, et al. Neurol Genet. 2021 Nov 12;7(6):e634. doi: 10.1212/NXG.0000000000000634. eCollection 2021 Dec. Neurol Genet. 2021. PMID: 34786478 Free PMC article.
BACKGROUND AND OBJECTIVES: To test the hypothesis that a predisposition to acquired genetic alterations is associated with ischemic stroke outcome by investigating the association between a polygenic risk score (PRS) for mosaic loss of chromosome …
BACKGROUND AND OBJECTIVES: To test the hypothesis that a predisposition to acquired genetic alterations is associated with ischemic s …
Particulate matter pollution, polygenic risk score and mosaic loss of chromosome Y in middle-aged and older men from the Dongfeng-Tongji cohort study.
Guan X, Meng X, Zhong G, Zhang Z, Wang C, Xiao Y, Fu M, Zhao H, Zhou Y, Hong S, Xu X, Bai Y, Kan H, Chen R, Wu T, Guo H. Guan X, et al. J Hazard Mater. 2024 Jun 5;471:134315. doi: 10.1016/j.jhazmat.2024.134315. Epub 2024 Apr 16. J Hazard Mater. 2024. PMID: 38678703
Mosaic loss of chromosome Y (mLOY) is the most common somatic alteration as men aging and may reflect genome instability. PM exposure is a major health concern worldwide, but its effects with genetic factors on mLOY has never been investigated. Here we …
Mosaic loss of chromosome Y (mLOY) is the most common somatic alteration as men aging and may reflect genome ins …
Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.
Wong JYY, Margolis HG, Machiela M, Zhou W, Odden MC, Psaty BM, Robbins J, Jones RR, Rotter JI, Chanock SJ, Rothman N, Lan Q, Lee JS. Wong JYY, et al. Environ Int. 2018 Jul;116:239-247. doi: 10.1016/j.envint.2018.04.030. Epub 2018 Apr 24. Environ Int. 2018. PMID: 29698900 Free PMC article.
BACKGROUND: Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear. OBJECTIVE: We …
BACKGROUND: Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially …
Polycyclic aromatic hydrocarbons exposure and their joint effects with age, smoking, and TCL1A variants on mosaic loss of chromosome Y among coke-oven workers.
Liu Y, Bai Y, Wu X, Li G, Wei W, Fu W, Wang G, Feng Y, Meng H, Li H, Li M, Guan X, Zhang X, He M, Wu T, Guo H. Liu Y, et al. Environ Pollut. 2020 Mar;258:113655. doi: 10.1016/j.envpol.2019.113655. Epub 2019 Nov 27. Environ Pollut. 2020. PMID: 31818624
Mosaic loss of chromosome Y (mLOY) is the most common structure somatic event that related to increased risks of various diseases and mortality. ...Our results revealed the linear dose-effect associations between PAHs exposure and mLOY. Elder ma …
Mosaic loss of chromosome Y (mLOY) is the most common structure somatic event that related to increased risks of …
13 results