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Year Number of Results
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4,443 results

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Page 1
Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells.
Ichikawa MK, Endo K, Itoh Y, Osada AH, Kimura Y, Ueki K, Yoshizawa K, Miyazawa K, Saitoh M. Ichikawa MK, et al. FEBS Open Bio. 2022 Jul;12(7):1353-1364. doi: 10.1002/2211-5463.13415. Epub 2022 Apr 29. FEBS Open Bio. 2022. PMID: 35451213 Free PMC article.
The epithelial-mesenchymal transition (EMT) is a crucial morphological event that occurs during epithelial tumor progression. Snail and ZEB1/2 (ZEB1 and ZEB2), known as EMT transcription factors, are key regulators of this transition. ...Here, we found that m …
The epithelial-mesenchymal transition (EMT) is a crucial morphological event that occurs during epithelial tumor progression. Snail a …
Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.
Nam E, Valeriano MO, Wang ZA, Whedon SD, Jiang H, Zhang MX, DuBois-Coyne S, Haque IA, Jiang J, Ferreira J, Farnung L, Lee K, Cole PA. Nam E, et al. Nucleic Acids Res. 2026 Jun 22;54(12):gkag600. doi: 10.1093/nar/gkag600. Nucleic Acids Res. 2026. PMID: 42376816 Free PMC article.
SNAIL is a transcription factor that plays a role in development and cancer. SNAIL contains an N-terminal SNAG domain that is a high-affinity ligand for the histone substrate binding lysine-specific demethylase 1 (LSD1). ...SNAIL and related …
SNAIL is a transcription factor that plays a role in development and cancer. SNAIL contains an N-terminal SNAG d …
The Snail transcription factor CES-1 regulates glutamatergic behavior in C. elegans.
Park L, Luth ES, Jones K, Hofer J, Nguyen I, Watters KE, Juo P. Park L, et al. PLoS One. 2021 Feb 2;16(2):e0245587. doi: 10.1371/journal.pone.0245587. eCollection 2021. PLoS One. 2021. PMID: 33529210 Free PMC article.
Regulation of AMPA-type glutamate receptor (AMPAR) expression and function alters synaptic strength and is a major mechanism underlying synaptic plasticity. Although transcription is required for some forms of synaptic plasticity, the transcription factors th …
Regulation of AMPA-type glutamate receptor (AMPAR) expression and function alters synaptic strength and is a major mechanism underlying syna …
Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells.
McKeithen D, Graham T, Chung LW, Odero-Marah V. McKeithen D, et al. Prostate. 2010 Jun 15;70(9):982-92. doi: 10.1002/pros.21132. Prostate. 2010. PMID: 20166136 Free PMC article.
BACKGROUND: Snail transcription factor induces epithelial-mesenchymal transition (EMT) via decreased cell adhesion-associated molecules like E-cadherin, and increased mesenchymal markers like vimentin. ...Additionally, NED in LNCaP-C33 cells or that induced i …
BACKGROUND: Snail transcription factor induces epithelial-mesenchymal transition (EMT) via decreased cell adhesion-asso …
Transcription factor snail modulates hormone expression in established endocrine pancreatic cell lines.
Rukstalis JM, Ubeda M, Johnson MV, Habener JF. Rukstalis JM, et al. Endocrinology. 2006 Jun;147(6):2997-3006. doi: 10.1210/en.2005-1396. Epub 2006 Mar 23. Endocrinology. 2006. PMID: 16556769
Here we present evidence that the zinc-finger transcription factor Snail modulates this transition in differentiated pancreatic endocrine cell lines. ...As the cells cluster and exit the cell division cycle, nuclear levels of Snail are reduced and horm …
Here we present evidence that the zinc-finger transcription factor Snail modulates this transition in differentiated pa …
The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation.
Ohkubo T, Ozawa M. Ohkubo T, et al. J Cell Sci. 2004 Apr 1;117(Pt 9):1675-85. doi: 10.1242/jcs.01004. Epub 2004 Mar 9. J Cell Sci. 2004. PMID: 15075229
Although occludin mRNA levels were downregulated by Snail expression, the transcription of claudin-1 and ZO-1 were unaffected. Reporter assays using the claudin-1 promoter region revealed that promoter activity was not affected by Snail overexpression. ...The …
Although occludin mRNA levels were downregulated by Snail expression, the transcription of claudin-1 and ZO-1 were unaffected. …
Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia.
Fedorova L, Gatto-Weis C, Smaili S, Khurshid N, Shapiro JI, Malhotra D, Horrigan T. Fedorova L, et al. Reprod Biol Endocrinol. 2012 Feb 23;10:15. doi: 10.1186/1477-7827-10-15. Reprod Biol Endocrinol. 2012. PMID: 22360878 Free PMC article.
BACKGROUND: Placental malfunction in preeclampsia is believed to be a consequence of aberrant differentiation of trophoblast lineages and changes in utero-placental oxygenation. The transcription factor Snail, a master regulator molecule of epithelial-mesench …
BACKGROUND: Placental malfunction in preeclampsia is believed to be a consequence of aberrant differentiation of trophoblast lineages and ch …
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.
Cano A, Pérez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA. Cano A, et al. Nat Cell Biol. 2000 Feb;2(2):76-83. doi: 10.1038/35000025. Nat Cell Biol. 2000. PMID: 10655586
The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial-mesenchymal transitions) during embryonic development. Epithelial-mesenchymal transitions are also de …
The Snail family of transcription factors has previously been implicated in the differentiation of epithelial ce …
Transcription factor snail regulates tumor necrosis factor alpha-mediated synovial fibroblast activation in the rheumatoid joint.
Chen SY, Shiau AL, Li YT, Lin CC, Jou IM, Liu MF, Wu CL, Wang CR. Chen SY, et al. Arthritis Rheumatol. 2015 Jan;67(1):39-50. doi: 10.1002/art.38899. Arthritis Rheumatol. 2015. PMID: 25303734
OBJECTIVE: The transcription factor Snail is involved in various biologic functions. We hypothesized that this molecule regulates tumor necrosis factor alpha (TNFalpha)-mediated synovial fibroblast activation in the rheumatoid joint. ...TNFalpha stimul …
OBJECTIVE: The transcription factor Snail is involved in various biologic functions. We hypothesized that this molecule …
Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells.
Neal CL, Henderson V, Smith BN, McKeithen D, Graham T, Vo BT, Odero-Marah VA. Neal CL, et al. BMC Cancer. 2012 Aug 2;12:336. doi: 10.1186/1471-2407-12-336. BMC Cancer. 2012. PMID: 22857708 Free PMC article.
BACKGROUND: Maspin, a putative tumor suppressor that is down-regulated in breast and prostate cancer, has been associated with decreased cell motility. Snail transcription factor is a zinc finger protein that is increased in breast cancer and is associated wi …
BACKGROUND: Maspin, a putative tumor suppressor that is down-regulated in breast and prostate cancer, has been associated with decreased cel …
4,443 results