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A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.
Yerabham ASK, Mas PJ, Decker C, Soares DC, Weiergräber OH, Nagel-Steger L, Willbold D, Hart DJ, Bradshaw NJ, Korth C. Yerabham ASK, et al. Among authors: soares dc. J Biol Chem. 2017 Apr 21;292(16):6468-6477. doi: 10.1074/jbc.M116.773903. Epub 2017 Mar 1. J Biol Chem. 2017. PMID: 28249940 Free PMC article.
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.
Soares DC, Bradshaw NJ, Zou J, Kennaway CK, Hamilton RS, Chen ZA, Wear MA, Blackburn EA, Bramham J, Böttcher B, Millar JK, Barlow PN, Walkinshaw MD, Rappsilber J, Porteous DJ. Soares DC, et al. J Biol Chem. 2012 Sep 21;287(39):32381-93. doi: 10.1074/jbc.M112.393439. Epub 2012 Jul 27. J Biol Chem. 2012. PMID: 22843697 Free PMC article.
The DISC locus in psychiatric illness.
Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK. Chubb JE, et al. Among authors: soares dc. Mol Psychiatry. 2008 Jan;13(1):36-64. doi: 10.1038/sj.mp.4002106. Epub 2007 Oct 2. Mol Psychiatry. 2008. PMID: 17912248 Review.
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
Eykelenboom JE, Briggs GJ, Bradshaw NJ, Soares DC, Ogawa F, Christie S, Malavasi EL, Makedonopoulou P, Mackie S, Malloy MP, Wear MA, Blackburn EA, Bramham J, McIntosh AM, Blackwood DH, Muir WJ, Porteous DJ, Millar JK. Eykelenboom JE, et al. Among authors: soares dc. Hum Mol Genet. 2012 Aug 1;21(15):3374-86. doi: 10.1093/hmg/dds169. Epub 2012 Apr 30. Hum Mol Genet. 2012. PMID: 22547224 Free PMC article.
NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction.
Bradshaw NJ, Christie S, Soares DC, Carlyle BC, Porteous DJ, Millar JK. Bradshaw NJ, et al. Among authors: soares dc. Neurosci Lett. 2009 Jan 16;449(3):228-33. doi: 10.1016/j.neulet.2008.10.095. Epub 2008 Nov 6. Neurosci Lett. 2009. PMID: 19000741 Free PMC article.
DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.
Porteous DJ, Thomson PA, Millar JK, Evans KL, Hennah W, Soares DC, McCarthy S, McCombie WR, Clapcote SJ, Korth C, Brandon NJ, Sawa A, Kamiya A, Roder JC, Lawrie SM, McIntosh AM, St Clair D, Blackwood DH. Porteous DJ, et al. Among authors: soares dc. Mol Psychiatry. 2014 Feb;19(2):141-3. doi: 10.1038/mp.2013.160. Mol Psychiatry. 2014. PMID: 24457522 Free PMC article. No abstract available.
133 results