Soars MG - Search Results

1

The pivotal role of hepatocytes in drug discovery.

Soars MG, McGinnity DF, Grime K, Riley RJ. Soars MG, et al. Chem Biol Interact. 2007 May 20;168(1):2-15. doi: 10.1016/j.cbi.2006.11.002. Epub 2006 Nov 18. Chem Biol Interact. 2007. PMID: 17208208 Review.

2

Application of an in vitro OAT assay in drug design and optimization of renal clearance.

Soars MG, Barton P, Elkin LL, Mosure KW, Sproston JL, Riley RJ. Soars MG, et al. Xenobiotica. 2014 Jul;44(7):657-65. doi: 10.3109/00498254.2013.879625. Epub 2014 Jan 13. Xenobiotica. 2014. PMID: 24417751

3

Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo.

Soars MG, Grime K, Sproston JL, Webborn PJ, Riley RJ. Soars MG, et al. Drug Metab Dispos. 2007 Jun;35(6):859-65. doi: 10.1124/dmd.106.014464. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344337

4

A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology.

Soars MG, Gelboin HV, Krausz KW, Riley RJ. Soars MG, et al. Br J Clin Pharmacol. 2003 Feb;55(2):175-81. doi: 10.1046/j.1365-2125.2003.01721.x. Br J Clin Pharmacol. 2003. PMID: 12580989 Free PMC article.

5

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance.

McGinnity DF, Soars MG, Urbanowicz RA, Riley RJ. McGinnity DF, et al. Among authors: soars mg. Drug Metab Dispos. 2004 Nov;32(11):1247-53. doi: 10.1124/dmd.104.000026. Epub 2004 Jul 30. Drug Metab Dispos. 2004. PMID: 15286053

6

Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s.

McGinnity DF, Parker AJ, Soars M, Riley RJ. McGinnity DF, et al. Drug Metab Dispos. 2000 Nov;28(11):1327-34. Drug Metab Dispos. 2000. PMID: 11038161

7

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance.

Soars MG, Burchell B, Riley RJ. Soars MG, et al. J Pharmacol Exp Ther. 2002 Apr;301(1):382-90. doi: 10.1124/jpet.301.1.382. J Pharmacol Exp Ther. 2002. PMID: 11907196

8

Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.

Soars MG, Grime K, Riley RJ. Soars MG, et al. Xenobiotica. 2006 Apr;36(4):287-99. doi: 10.1080/00498250500446208. Xenobiotica. 2006. PMID: 16684709

9

Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA.

Williamson B, Soars AC, Owen A, White P, Riley RJ, Soars MG. Williamson B, et al. Among authors: soars ac, soars mg. Xenobiotica. 2013 Oct;43(10):920-31. doi: 10.3109/00498254.2013.776194. Epub 2013 Mar 6. Xenobiotica. 2013. PMID: 23461378

10

Hepatic drug transporters: the journey so far.

Riley RJ, Foley SA, Barton P, Soars MG, Williamson B. Riley RJ, et al. Among authors: soars mg. Expert Opin Drug Metab Toxicol. 2016;12(2):201-16. doi: 10.1517/17425255.2016.1132308. Epub 2016 Jan 8. Expert Opin Drug Metab Toxicol. 2016. PMID: 26670591 Review.

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