Sobczak K - Search Results

1

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, Disney MD. Childs-Disney JL, et al. Among authors: sobczak k. Nat Commun. 2013;4:2044. doi: 10.1038/ncomms3044. Nat Commun. 2013. PMID: 23806903 Free PMC article.

2

Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.

Yuan Y, Compton SA, Sobczak K, Stenberg MG, Thornton CA, Griffith JD, Swanson MS. Yuan Y, et al. Among authors: sobczak k. Nucleic Acids Res. 2007;35(16):5474-86. doi: 10.1093/nar/gkm601. Epub 2007 Aug 15. Nucleic Acids Res. 2007. PMID: 17702765 Free PMC article.

3

Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

Gareiss PC, Sobczak K, McNaughton BR, Palde PB, Thornton CA, Miller BL. Gareiss PC, et al. Among authors: sobczak k. J Am Chem Soc. 2008 Dec 3;130(48):16254-61. doi: 10.1021/ja804398y. J Am Chem Soc. 2008. PMID: 18998634 Free PMC article.

4

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.

Osborne RJ, Lin X, Welle S, Sobczak K, O'Rourke JR, Swanson MS, Thornton CA. Osborne RJ, et al. Among authors: sobczak k. Hum Mol Genet. 2009 Apr 15;18(8):1471-81. doi: 10.1093/hmg/ddp058. Epub 2009 Feb 17. Hum Mol Genet. 2009. PMID: 19223393 Free PMC article.

5

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

Pushechnikov A, Lee MM, Childs-Disney JL, Sobczak K, French JM, Thornton CA, Disney MD. Pushechnikov A, et al. Among authors: sobczak k. J Am Chem Soc. 2009 Jul 22;131(28):9767-79. doi: 10.1021/ja9020149. J Am Chem Soc. 2009. PMID: 19552411 Free PMC article.

6

Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA.

Wheeler TM, Sobczak K, Lueck JD, Osborne RJ, Lin X, Dirksen RT, Thornton CA. Wheeler TM, et al. Among authors: sobczak k. Science. 2009 Jul 17;325(5938):336-9. doi: 10.1126/science.1173110. Science. 2009. PMID: 19608921 Free PMC article.

7

Scaled-down genetic analysis of myotonic dystrophy type 1 and type 2.

Nakamori M, Sobczak K, Moxley RT 3rd, Thornton CA. Nakamori M, et al. Among authors: sobczak k. Neuromuscul Disord. 2009 Nov;19(11):759-62. doi: 10.1016/j.nmd.2009.07.012. Epub 2009 Aug 26. Neuromuscul Disord. 2009. PMID: 19713112 Free PMC article.

8

Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy.

Lee MM, Childs-Disney JL, Pushechnikov A, French JM, Sobczak K, Thornton CA, Disney MD. Lee MM, et al. Among authors: sobczak k. J Am Chem Soc. 2009 Dec 2;131(47):17464-72. doi: 10.1021/ja906877y. J Am Chem Soc. 2009. PMID: 19904940 Free PMC article.

9

Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel.

Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA. Tang ZZ, et al. Among authors: sobczak k. Hum Mol Genet. 2012 Mar 15;21(6):1312-24. doi: 10.1093/hmg/ddr568. Epub 2011 Dec 2. Hum Mol Genet. 2012. PMID: 22140091 Free PMC article.

10

Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

Chen CZ, Sobczak K, Hoskins J, Southall N, Marugan JJ, Zheng W, Thornton CA, Austin CP. Chen CZ, et al. Among authors: sobczak k. Anal Bioanal Chem. 2012 Feb;402(5):1889-98. doi: 10.1007/s00216-011-5604-0. Epub 2012 Jan 5. Anal Bioanal Chem. 2012. PMID: 22218462 Free PMC article.

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