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Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Kleinewietfeld M, et al. Nature. 2013 Apr 25;496(7446):518-22. doi: 10.1038/nature11868. Epub 2013 Mar 6. Nature. 2013. PMID: 23467095 Free PMC article.
Here we show that increased salt (sodium chloride, NaCl) concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human TH17 cells. ...Thus, increased dietary salt intake might represent an environmental r …
Here we show that increased salt (sodium chloride, NaCl) concentrations found locally under physiological conditions in vivo m …
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mähler A, Balogh A, Markó L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Frätzer C, Krannich A, Gollasch M, Grohme DA, Côrte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Müller DN. Wilck N, et al. Nature. 2017 Nov 30;551(7682):585-589. doi: 10.1038/nature24628. Epub 2017 Nov 15. Nature. 2017. PMID: 29143823 Free PMC article.
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (T(H)17) cells, which can also contribute to hypertension. ...Consequently, treatment of mice wi …
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally dri
Sodium Chloride Aggravates Arthritis via Th17 Polarization.
Jung SM, Kim Y, Kim J, Jung H, Yi H, Rim YA, Park N, Kwok SK, Park SH, Ju JH. Jung SM, et al. Yonsei Med J. 2019 Jan;60(1):88-97. doi: 10.3349/ymj.2019.60.1.88. Yonsei Med J. 2019. PMID: 30554495 Free PMC article.
PURPOSE: Sodium chloride (NaCl) has been proposed as a driving factor in autoimmune diseases through the induction of pathogenic CD4(+) T helper cells that produce interleukin-17 (Th17 cells). ...We also analyzed the effect of NaCl on Th1 …
PURPOSE: Sodium chloride (NaCl) has been proposed as a driving factor in autoimmune diseases through the …
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