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Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.
Sandham DA, Arnold N, Aschauer H, Bala K, Barker L, Brown L, Brown Z, Budd D, Cox B, Docx C, Dubois G, Duggan N, England K, Everatt B, Furegati M, Hall E, Kalthoff F, King A, Leblanc CJ, Manini J, Meingassner J, Profit R, Schmidt A, Simmons J, Sohal B, Stringer R, Thomas M, Turner KL, Walker C, Watson SJ, Westwick J, Willis J, Williams G, Wilson C. Sandham DA, et al. Among authors: sohal b. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91. doi: 10.1016/j.bmc.2013.08.025. Epub 2013 Aug 22. Bioorg Med Chem. 2013. PMID: 24021582
Application of a deuterium replacement strategy to modulate the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a novel CRF1 antagonist.
Stringer RA, Williams G, Picard F, Sohal B, Kretz O, McKenna J, Krauser JA. Stringer RA, et al. Among authors: sohal b. Drug Metab Dispos. 2014 May;42(5):954-62. doi: 10.1124/dmd.114.057265. Epub 2014 Mar 10. Drug Metab Dispos. 2014. PMID: 24616265
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma.
Sandham DA, Barker L, Brown L, Brown Z, Budd D, Charlton SJ, Chatterjee D, Cox B, Dubois G, Duggan N, Hall E, Hatto J, Maas J, Manini J, Profit R, Riddy D, Ritchie C, Sohal B, Shaw D, Stringer R, Sykes DA, Thomas M, Turner KL, Watson SJ, West R, Willard E, Williams G, Willis J. Sandham DA, et al. Among authors: sohal b. ACS Med Chem Lett. 2017 Apr 25;8(5):582-586. doi: 10.1021/acsmedchemlett.7b00157. eCollection 2017 May 11. ACS Med Chem Lett. 2017. PMID: 28523115 Free PMC article.
Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
Russell MG, Carling RW, Street LJ, Hallett DJ, Goodacre S, Mezzogori E, Reader M, Cook SM, Bromidge FA, Newman R, Smith AJ, Wafford KA, Marshall GR, Reynolds DS, Dias R, Ferris P, Stanley J, Lincoln R, Tye SJ, Sheppard WF, Sohal B, Pike A, Dominguez M, Atack JR, Castro JL. Russell MG, et al. Among authors: sohal b. J Med Chem. 2006 Feb 23;49(4):1235-8. doi: 10.1021/jm051200u. J Med Chem. 2006. PMID: 16480260
2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists.
Russell MG, Beer MS, Stanton JA, Sohal B, Mortishire-Smith RJ, Castro JL. Russell MG, et al. Among authors: sohal b. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2491-6. doi: 10.1016/s0960-894x(99)00409-6. Bioorg Med Chem Lett. 1999. PMID: 10498195
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