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Through the looking glass--a new world of proteins enabled by chemical synthesis.
Kent S, Sohma Y, Liu S, Bang D, Pentelute B, Mandal K. Kent S, et al. J Pept Sci. 2012 Jul;18(7):428-36. doi: 10.1002/psc.2421. Epub 2012 Jun 4. J Pept Sci. 2012. PMID: 22674813 Review.
O-acyl isopeptide method: development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1-42 isopeptide.
Yoshiya T, Uemura T, Maruno T, Kubo S, Kiso Y, Sohma Y, Kobayashi Y, Yoshizawa-Kumagaye K, Nishiuchi Y. Yoshiya T, et al. J Pept Sci. 2014 Sep;20(9):669-74. doi: 10.1002/psc.2662. Epub 2014 May 28. J Pept Sci. 2014. PMID: 24889810
Epimerization-free synthesis of cyclic peptide by use of the O-acyl isopeptide method.
Yoshiya T, Kawashima H, Hasegawa Y, Okamoto K, Kimura T, Sohma Y, Kiso Y. Yoshiya T, et al. J Pept Sci. 2010 Aug;16(8):437-42. doi: 10.1002/psc.1261. J Pept Sci. 2010. PMID: 20623499
'O-Acyl isopeptide method' for peptide synthesis: Solvent effects in the synthesis of Abeta1-42 isopeptide using 'O-acyl isodipeptide unit'.
Taniguchi A, Yoshiya T, Abe N, Fukao F, Sohma Y, Kimura T, Hayashi Y, Kiso Y. Taniguchi A, et al. J Pept Sci. 2007 Dec;13(12):868-74. doi: 10.1002/psc.905. J Pept Sci. 2007. PMID: 17803257
'Click peptide': a novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues.
Sohma Y, Taniguchi A, Yoshiya T, Chiyomori Y, Fukao F, Nakamura S, Skwarczynski M, Okada T, Ikeda K, Hayashi Y, Kimura T, Hirota S, Matsuzaki K, Kiso Y. Sohma Y, et al. J Pept Sci. 2006 Dec;12(12):823-8. doi: 10.1002/psc.817. J Pept Sci. 2006. PMID: 17131295
The 'O-acyl isopeptide method' for the synthesis of difficult sequence-containing peptides: application to the synthesis of Alzheimer's disease-related amyloid beta peptide (Abeta) 1-42.
Sohma Y, Hayashi Y, Kimura M, Chiyomori Y, Taniguchi A, Sasaki M, Kimura T, Kiso Y. Sohma Y, et al. J Pept Sci. 2005 Jul;11(8):441-51. doi: 10.1002/psc.649. J Pept Sci. 2005. PMID: 15761877
Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulin.
Sohma Y, Hua QX, Whittaker J, Weiss MA, Kent SB. Sohma Y, et al. Angew Chem Int Ed Engl. 2010 Jul 26;49(32):5489-93. doi: 10.1002/anie.201001151. Angew Chem Int Ed Engl. 2010. PMID: 20509131 Free PMC article. No abstract available.
Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.
Sohma Y, Hua QX, Liu M, Phillips NB, Hu SQ, Whittaker J, Whittaker LJ, Ng A, Roberts CT Jr, Arvan P, Kent SB, Weiss MA. Sohma Y, et al. J Biol Chem. 2010 Feb 12;285(7):5040-55. doi: 10.1074/jbc.M109.062992. Epub 2009 Dec 3. J Biol Chem. 2010. PMID: 19959476 Free PMC article.
Comparative properties of insulin-like growth factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 prepared by total chemical synthesis.
Sohma Y, Pentelute BL, Whittaker J, Hua QX, Whittaker LJ, Weiss MA, Kent SB. Sohma Y, et al. Angew Chem Int Ed Engl. 2008;47(6):1102-6. doi: 10.1002/anie.200703521. Angew Chem Int Ed Engl. 2008. PMID: 18161716 No abstract available.
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