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PML is a ROS sensor activating p53 upon oxidative stress.
Niwa-Kawakita M, Ferhi O, Soilihi H, Le Bras M, Lallemand-Breitenbach V, de Thé H. Niwa-Kawakita M, et al. Among authors: soilihi h. J Exp Med. 2017 Nov 6;214(11):3197-3206. doi: 10.1084/jem.20160301. Epub 2017 Sep 20. J Exp Med. 2017. PMID: 28931625 Free PMC article.
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.
Nasr R, Guillemin MC, Ferhi O, Soilihi H, Peres L, Berthier C, Rousselot P, Robledo-Sarmiento M, Lallemand-Breitenbach V, Gourmel B, Vitoux D, Pandolfi PP, Rochette-Egly C, Zhu J, de Thé H. Nasr R, et al. Among authors: soilihi h. Nat Med. 2008 Dec;14(12):1333-42. doi: 10.1038/nm.1891. Epub 2008 Nov 23. Nat Med. 2008. PMID: 19029980