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A DEAD protein that activates intron self-splicing without unwinding RNA.
Solem A, Zingler N, Pyle AM. Solem A, et al. Mol Cell. 2006 Nov 17;24(4):611-7. doi: 10.1016/j.molcel.2006.10.032. Mol Cell. 2006. PMID: 17188036
Here we show that Mss116 can stimulate splicing of ai5gamma under near-physiological conditions in vitro, which represents one of the first cases in which a DExH/D protein is shown to act on its natural target. Importantly, we demonstrate that a small subset of DEAD …
Here we show that Mss116 can stimulate splicing of ai5gamma under near-physiological conditions in vitro, which represents one of the first …
Protein-facilitated ribozyme folding and catalysis.
Zingler N, Solem A, Pyle AM. Zingler N, et al. Nucleic Acids Symp Ser (Oxf). 2008;(52):67-8. doi: 10.1093/nass/nrn034. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776256
However, it is a matter of debate whether it does this by stabilizing on-pathway intermediates or by disrupting misfolded structures. ...
However, it is a matter of debate whether it does this by stabilizing on-pathway intermediates or by disrupting misfolded structures. …
The NPH-II helicase displays efficient DNA x RNA helicase activity and a pronounced purine sequence bias.
Taylor SD, Solem A, Kawaoka J, Pyle AM. Taylor SD, et al. J Biol Chem. 2010 Apr 9;285(15):11692-703. doi: 10.1074/jbc.M109.088559. Epub 2010 Jan 28. J Biol Chem. 2010. PMID: 20110368 Free PMC article.
The observed sequence bias allows NPH-II to efficiently unwind a DNA x RNA hybrid containing a purine-rich DNA track derived from the 3'-untranslated region of an early vaccinia gene. ...
The observed sequence bias allows NPH-II to efficiently unwind a DNA x RNA hybrid containing a purine-rich DNA track derived f …
Dual roles for the Mss116 cofactor during splicing of the ai5γ group II intron.
Zingler N, Solem A, Pyle AM. Zingler N, et al. Nucleic Acids Res. 2010 Oct;38(19):6602-9. doi: 10.1093/nar/gkq530. Epub 2010 Jun 16. Nucleic Acids Res. 2010. PMID: 20554854 Free PMC article.
By comparing intron precursor RNAs with long (∼300 nt) and short (∼20 nt) exons, we observe that long exon sequences are a major obstacle for self-splicing in vitro. ...Strong parallels between Mss116 and the related protein Cyt-19 from Neurospora crassa suggest that these …
By comparing intron precursor RNAs with long (∼300 nt) and short (∼20 nt) exons, we observe that long exon sequences are a major obst …
Protein-facilitated folding of group II intron ribozymes.
Fedorova O, Solem A, Pyle AM. Fedorova O, et al. J Mol Biol. 2010 Apr 2;397(3):799-813. doi: 10.1016/j.jmb.2010.02.001. Epub 2010 Feb 6. J Mol Biol. 2010. PMID: 20138894 Free PMC article.
Using native gel electrophoresis and dimethyl sulfate structural probing, we monitored Mss-116-facilitated folding of ai5gamma intron ribozymes and a catalytically active self-splicing RNA containing full-length intron and short exons. ...Results obtained from experiments …
Using native gel electrophoresis and dimethyl sulfate structural probing, we monitored Mss-116-facilitated folding of ai5gamma intron ribozy …
An allosteric-feedback mechanism for protein-assisted group I intron splicing.
Caprara MG, Chatterjee P, Solem A, Brady-Passerini KL, Kaspar BJ. Caprara MG, et al. RNA. 2007 Feb;13(2):211-22. doi: 10.1261/rna.307907. Epub 2006 Dec 12. RNA. 2007. PMID: 17164477 Free PMC article.
The I-AniI maturase facilitates self-splicing of a mitochondrial group I intron in Aspergillus nidulans. Binding occurs in at least two steps: first, a specific but labile encounter complex rapidly forms and then this intermediate is slowly resolved into a na …
The I-AniI maturase facilitates self-splicing of a mitochondrial group I intron in Aspergillus nidulans. Binding occurs in at least t …
A novel mechanism for protein-assisted group I intron splicing.
Solem A, Chatterjee P, Caprara MG. Solem A, et al. RNA. 2002 Apr;8(4):412-25. doi: 10.1017/s1355838202029321. RNA. 2002. PMID: 11991637 Free PMC article.
Our results are consistent with I-AniI and A.n. COB pre-RNA forming a specific but labile encounter complex that is resolved into the native, splicing-competent complex. ...These results, taken together with the observation that A.n. COB intron lacks signific …
Our results are consistent with I-AniI and A.n. COB pre-RNA forming a specific but labile encounter complex that is resolved i …
Functionally distinct nucleic acid binding sites for a group I intron encoded RNA maturase/DNA homing endonuclease.
Chatterjee P, Brady KL, Solem A, Ho Y, Caprara MG. Chatterjee P, et al. J Mol Biol. 2003 May 30;329(2):239-51. doi: 10.1016/s0022-2836(03)00426-1. J Mol Biol. 2003. PMID: 12758073
A large number of group I introns encode a family of homologous proteins that either promote intron splicing (maturases) or are site-specific DNA endonucleases that function in intron mobility (a process called "homing"). ...Since RNA splicing is likely a
A large number of group I introns encode a family of homologous proteins that either promote intron splicing (maturases) or ar
Single-molecule analysis of Mss116-mediated group II intron folding.
Karunatilaka KS, Solem A, Pyle AM, Rueda D. Karunatilaka KS, et al. Among authors: solem a. Nature. 2010 Oct 21;467(7318):935-9. doi: 10.1038/nature09422. Epub 2010 Oct 13. Nature. 2010. PMID: 20944626 Free PMC article.
Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark.
Corley M, Solem A, Qu K, Chang HY, Laederach A. Corley M, et al. Among authors: solem a. Nucleic Acids Res. 2015 Feb 18;43(3):1859-68. doi: 10.1093/nar/gkv010. Epub 2015 Jan 23. Nucleic Acids Res. 2015. PMID: 25618847 Free PMC article.
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