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Resistance to BRAF inhibition in melanomas.
Solit DB, Rosen N. Solit DB, et al. N Engl J Med. 2011 Feb 24;364(8):772-4. doi: 10.1056/NEJMcibr1013704. N Engl J Med. 2011. PMID: 21345109 No abstract available.
Development of purine-scaffold small molecule inhibitors of Hsp90.
Chiosis G, Lucas B, Huezo H, Solit D, Basso A, Rosen N. Chiosis G, et al. Curr Cancer Drug Targets. 2003 Oct;3(5):371-6. doi: 10.2174/1568009033481778. Curr Cancer Drug Targets. 2003. PMID: 14529388 Review.
Hsp90 as a therapeutic target in prostate cancer.
Solit DB, Scher HI, Rosen N. Solit DB, et al. Semin Oncol. 2003 Oct;30(5):709-16. doi: 10.1016/s0093-7754(03)00346-4. Semin Oncol. 2003. PMID: 14571418 Review.
Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.
Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P, Chiosis G. Vilenchik M, et al. Chem Biol. 2004 Jun;11(6):787-97. doi: 10.1016/j.chembiol.2004.04.008. Chem Biol. 2004. PMID: 15217612
Hsp90: the vulnerable chaperone.
Chiosis G, Vilenchik M, Kim J, Solit D. Chiosis G, et al. Drug Discov Today. 2004 Oct 15;9(20):881-8. doi: 10.1016/S1359-6446(04)03245-3. Drug Discov Today. 2004. PMID: 15475321 Review.
BRAF mutation predicts sensitivity to MEK inhibition.
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. Solit DB, et al. Nature. 2006 Jan 19;439(7074):358-62. doi: 10.1038/nature04304. Epub 2005 Nov 6. Nature. 2006. PMID: 16273091 Free PMC article.
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.
Grbovic OM, Basso AD, Sawai A, Ye Q, Friedlander P, Solit D, Rosen N. Grbovic OM, et al. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):57-62. doi: 10.1073/pnas.0609973103. Epub 2005 Dec 21. Proc Natl Acad Sci U S A. 2006. PMID: 16371460 Free PMC article.
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, Baselga J, Rosen N. O'Reilly KE, et al. Cancer Res. 2006 Feb 1;66(3):1500-8. doi: 10.1158/0008-5472.CAN-05-2925. Cancer Res. 2006. PMID: 16452206 Free PMC article.
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