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Year Number of Results
2010 1
2012 1
2013 2
2014 1
2015 2
2016 2
2017 1
2019 3
2020 1
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13 results
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Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.
El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH. El-Naggar AM, et al. Among authors: Somasekharan SP. Cancer Cell. 2015 May 11;27(5):682-97. doi: 10.1016/j.ccell.2015.04.003. Cancer Cell. 2015. PMID: 25965573 Free article.
YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.
Somasekharan SP, El-Naggar A, Leprivier G, Cheng H, Hajee S, Grunewald TG, Zhang F, Ng T, Delattre O, Evdokimova V, Wang Y, Gleave M, Sorensen PH. Somasekharan SP, et al. J Cell Biol. 2015 Mar 30;208(7):913-29. doi: 10.1083/jcb.201411047. Epub 2015 Mar 23. J Cell Biol. 2015. PMID: 25800057 Free PMC article.
eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.
Jan A, Jansonius B, Delaidelli A, Somasekharan SP, Bhanshali F, Vandal M, Negri GL, Moerman D, MacKenzie I, Calon F, Hayden MR, Taubert S, Sorensen PH. Jan A, et al. Among authors: Somasekharan SP. Acta Neuropathol. 2017 Jan;133(1):101-119. doi: 10.1007/s00401-016-1634-1. Epub 2016 Oct 17. Acta Neuropathol. 2017. PMID: 27752775
Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes.
Panasenko OO, Somasekharan SP, Villanyi Z, Zagatti M, Bezrukov F, Rashpa R, Cornut J, Iqbal J, Longis M, Carl SH, Peña C, Panse VG, Collart MA. Panasenko OO, et al. Among authors: Somasekharan SP. Nat Struct Mol Biol. 2019 Feb;26(2):110-120. doi: 10.1038/s41594-018-0179-5. Epub 2019 Jan 28. Nat Struct Mol Biol. 2019. PMID: 30692646
An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity.
Somasekharan SP, El-Naggar A, Sorensen PH, Wang Y, Cheng H. Somasekharan SP, et al. Evid Based Complement Alternat Med. 2016;2016:9730654. doi: 10.1155/2016/9730654. Epub 2016 Aug 31. Evid Based Complement Alternat Med. 2016. PMID: 27656243 Free PMC article.
Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer.
Kretschmer A, Zhang F, Somasekharan SP, Tse C, Leachman L, Gleave A, Li B, Asmaro I, Huang T, Kotula L, Sorensen PH, Gleave ME. Kretschmer A, et al. Among authors: Somasekharan SP. Sci Rep. 2019 May 24;9(1):7826. doi: 10.1038/s41598-019-44346-5. Sci Rep. 2019. PMID: 31127190 Free PMC article.
Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.
El-Naggar AM, Somasekharan SP, Wang Y, Cheng H, Negri GL, Pan M, Wang XQ, Delaidelli A, Rafn B, Cran J, Zhang F, Zhang H, Colborne S, Gleave M, Mandinova A, Kedersha N, Hughes CS, Surdez D, Delattre O, Wang Y, Huntsman DG, Morin GB, Sorensen PH. El-Naggar AM, et al. Among authors: Somasekharan SP. EMBO Rep. 2019 Dec 5;20(12):e48375. doi: 10.15252/embr.201948375. Epub 2019 Oct 31. EMBO Rep. 2019. PMID: 31668005 Free PMC article.
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH. Rotblat B, et al. Among authors: Somasekharan SP. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516159 Free PMC article.
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
Leprivier G, Remke M, Rotblat B, Dubuc A, Mateo AR, Kool M, Agnihotri S, El-Naggar A, Yu B, Somasekharan SP, Faubert B, Bridon G, Tognon CE, Mathers J, Thomas R, Li A, Barokas A, Kwok B, Bowden M, Smith S, Wu X, Korshunov A, Hielscher T, Northcott PA, Galpin JD, Ahern CA, Wang Y, McCabe MG, Collins VP, Jones RG, Pollak M, Delattre O, Gleave ME, Jan E, Pfister SM, Proud CG, Derry WB, Taylor MD, Sorensen PH. Leprivier G, et al. Among authors: Somasekharan SP. Cell. 2013 May 23;153(5):1064-79. doi: 10.1016/j.cell.2013.04.055. Cell. 2013. PMID: 23706743 Free PMC article.
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