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Leptin receptor expression and cell signaling in breast cancer.
Frankenberry KA, Skinner H, Somasundar P, McFadden DW, Vona-Davis LC. Frankenberry KA, et al. Int J Oncol. 2006 Apr;28(4):985-93. Int J Oncol. 2006. PMID: 16525650
Inhibition of melanoma growth by hemocyanin occurs via early apoptotic pathways.
Somasundar P, Riggs DR, Jackson BJ, McFadden DW. Somasundar P, et al. Am J Surg. 2005 Nov;190(5):713-6. doi: 10.1016/j.amjsurg.2005.07.008. Am J Surg. 2005. PMID: 16226945
Inositol hexaphosphate (IP6): a novel treatment for pancreatic cancer.
Somasundar P, Riggs DR, Jackson BJ, Cunningham C, Vona-Davis L, McFadden DW. Somasundar P, et al. J Surg Res. 2005 Jun 15;126(2):199-203. doi: 10.1016/j.jss.2005.01.022. J Surg Res. 2005. PMID: 15919420

RESULTS: Significant reductions (P < 0.01) in cellular proliferation were observed with all IP6 concentrations tested in both cell lines and at both time points. ...IP6 increased early and late apoptotic activity (P < 0.01). CONCLUSIONS: Treatment of pancreati

RESULTS: Significant reductions (P < 0.01) in cellular proliferation were observed with all IP6 concentrations tested in both cell

Prostate cancer cell proliferation is influenced by leptin.
Somasundar P, Frankenberry KA, Skinner H, Vedula G, McFadden DW, Riggs D, Jackson B, Vangilder R, Hileman SM, Vona-Davis LC. Somasundar P, et al. J Surg Res. 2004 May 1;118(1):71-82. doi: 10.1016/j.jss.2004.01.017. J Surg Res. 2004. PMID: 15093720

Multiplex RT-PCR was performed to determine mRNA levels of the short (huOB-Ra) or the long (huOB-Rb) OB-R isoforms or SOCS-3. p-Akt and p-ERK were determined by Western blot. ...Leptin increased SOCS-3 mRNA in DU145 at 24 and 48 h (P < 0.05) and in PC-3 at

Multiplex RT-PCR was performed to determine mRNA levels of the short (huOB-Ra) or the long (huOB-Rb) OB-R isoforms or SOCS-3. p-Akt a …
Leptin is a growth factor in cancer.
Somasundar P, McFadden DW, Hileman SM, Vona-Davis L. Somasundar P, et al. J Surg Res. 2004 Feb;116(2):337-49. doi: 10.1016/j.jss.2003.09.004. J Surg Res. 2004. PMID: 15013374 Review. No abstract available.
Leptin stimulates esophageal adenocarcinoma growth by nonapoptotic mechanisms.
Somasundar P, Riggs D, Jackson B, Vona-Davis L, McFadden DW. Somasundar P, et al. Am J Surg. 2003 Nov;186(5):575-8. doi: 10.1016/j.amjsurg.2003.07.017. Am J Surg. 2003. PMID: 14599628
Differential effects of leptin on cancer in vitro.
Somasundar P, Yu AK, Vona-Davis L, McFadden DW. Somasundar P, et al. J Surg Res. 2003 Jul;113(1):50-5. doi: 10.1016/s0022-4804(03)00166-5. J Surg Res. 2003. PMID: 12943810
Leptin caused growth potentiation in breast, esophagus, and prostate cancer (P < 0.05). However, in both Mia-PaCa and PANC-1 pancreatic cancer cells, leptin inhibited growth (P < 0.05). ...

Leptin caused growth potentiation in breast, esophagus, and prostate cancer (P < 0.05). However, in both Mia-PaCa and PANC-1 pancr

The evolving management of blunt hepatic trauma in a rural setting.
Somasundar PS, Mucha P, McFadden DW. Somasundar PS, et al. Am Surg. 2004 Jan;70(1):45-8. Am Surg. 2004. PMID: 14964546

When comparing the two groups, statistical significance was obtained in mean hospital length of stay (LOS) [19.8 days A vs. 9.1 days B (P < 0.0001)]; mean intensive care unit (ICU) days [15.2 days A vs. 5.3 days B (P < 0.0001)], blood transfusion [10 units A v

When comparing the two groups, statistical significance was obtained in mean hospital length of stay (LOS) [19.8 days A vs. 9.1 days B (P
Vitamin E and the Y4 agonist BA-129 decrease prostate cancer growth and production of vascular endothelial growth factor.
Yu A, Somasundar P, Balsubramaniam A, Rose AT, Vona-Davis L, McFadden DW. Yu A, et al. J Surg Res. 2002 Jun 1;105(1):65-8. doi: 10.1006/jsre.2002.6454. J Surg Res. 2002. PMID: 12069504

RESULTS: ATS exhibited significant (P < 0.05) growth inhibitory effects in prostate cancer cells. PYY also inhibited growth (P < 0.05). ATS treatment reduced VEGF production (P < 0.05). PYY treatment increased VEGF. When ATS was given in combination

RESULTS: ATS exhibited significant (P < 0.05) growth inhibitory effects in prostate cancer cells. PYY also inhibited growth (P

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