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Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.
Blair RE, Deshpande LS, Sombati S, Elphick MR, Martin BR, DeLorenzo RJ. Blair RE, et al. Among authors: sombati s. Neuropharmacology. 2009 Sep;57(3):208-18. doi: 10.1016/j.neuropharm.2009.06.007. Epub 2009 Jun 18. Neuropharmacology. 2009. PMID: 19540252 Free PMC article.
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