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Some experiences and opportunities for big data in translational research.
Chute CG, Ullman-Cullere M, Wood GM, Lin SM, He M, Pathak J. Chute CG, et al. Genet Med. 2013 Oct;15(10):802-9. doi: 10.1038/gim.2013.121. Epub 2013 Sep 5. Genet Med. 2013. PMID: 24008998 Free PMC article. Review.
Translational research in the present day increasingly embraces new biomedical discovery in this data-intensive world, thus entering the domain of "big data." The Electronic Medical Records and Genomics consortium has taught us many lesso
Translational research in the present day increasingly embraces new biomedical discovery in this data-intensive world,
Proceedings of the 8th Annual Conference on the Science of Dissemination and Implementation : Washington, DC, USA. 14-15 December 2015.
Chambers D, Simpson L, Hill-Briggs F, Neta G, Vinson C, Chambers D, Beidas R, Marcus S, Aarons G, Hoagwood K, Schoenwald S, Evans A, Hurford M, Rubin R, Hadley T, Barg F, Walsh L, Adams D, Mandell D, Martin L, Mignogna J, Mott J, Hundt N, Kauth M, Kunik M, Naik A, Cully J, McGuire A, White D, Bartholomew T, McGrew J, Luther L, Rollins A, Salyers M, Cooper B, Funaiole A, Richards J, Lee A, Lapham G, Caldeiro R, Lozano P, Gildred T, Achtmeyer C, Ludman E, Addis M, Marx L, Bradley K, VanDeinse T, Wilson AB, Stacey B, Powell B, Bunger A, Cuddeback G, Barnett M, Stadnick N, Brookman-Frazee L, Lau A, Dorsey S, Pullmann M, Mitchell S, Schwartz R, Kirk A, Dusek K, Oros M, Hosler C, Gryczynski J, Barbosa C, Dunlap L, Lounsbury D, O’Grady K, Brown B, Damschroder L, Waltz T, Powell B, Ritchie M, Waltz T, Atkins D, Imel ZE, Xiao B, Can D, Georgiou P, Narayanan S, Berkel C, Gallo C, Sandler I, Brown CH, Wolchik S, Mauricio AM, Gallo C, Brown CH, Mehrotra S, Chandurkar D, Bora S, Das A, Tripathi A, Saggurti N, Raj A, Hughes E, Jacobs B, Kirkendall E, Loeb D, Trinkley K, Yang M, Sprowell A, Nease D, Lyon A, Lewis C, Boyd M, Melvin A, Nicodimos S, Liu F, Jungbluth N, Lyon A, Lewis C, Boyd M, Melvin A, Nicodimos S, Liu F, Jungbluth N, Flynn A, Landis-Lewis Z, Sales A, Baloh J, Ward M, Zhu X, Bennett I, Unutzer J, Mao J, Proctor E, Vredevoogd M, Chan YF, Williams N, Green P, Bernstein S, Rosner JM, DeWitt M, Tetrault J, Dziura J, Hsiao A, Sussman S, O’Connor P, Toll B, Jones M, Gassaway J, Tobin J, Zatzick D, Bradbury AR, Patrick-Miller L, Egleston B, Olopade OI, Hall MJ, Daly MB, Fleisher L, Grana G, Ganschow P, Fetzer D, Brandt A, Farengo-Clark D, Forman A, Gaber RS, Gulden C, Horte J, Long J, Chambers RL, Lucas T, Madaan S, Mattie K, McKenna D, Montgomery S, Nielsen S, Powers J, Rainey K, Rybak C, Savage M, Seelaus C, Stoll J, Stopfer J, Yao S, Domchek S, Hahn E, Munoz-Plaza C, Wang J, Delgadillo JG, Mittman B, Gould M, Liang S, Kegler MC, Cotter M, Phillips E, Hermstad A, Morton R, Beasley D, Martinez J, Riehman K, Gustafson D, Marsch L, Mares L, Quanbeck A, McTavish F, McDowell H, Brown R, Thomas C, Glass J, Isham J, Shah D, Liebschutz J, Lasser K, Watkins K, Ober A, Hunter S, Lamp K, Ewing B, Iwelunmor J, Gyamfi J, Blackstone S, Quakyi NK, Plange-Rhule J, Ogedegbe G, Kumar P, Van Devanter N, Nguyen N, Nguyen L, Nguyen T, Phuong N, Shelley D, Rudge S, Langlois E, Tricco A, Ball S, Lambert-Kerzner A, Sulc C, Simmons C, Shell-Boyd J, Oestreich T, O’Connor A, Neely E, McCreight M, Labebue A, DiFiore D, Brostow D, Ho PM, Aron D, Harvey J, McHugh M, Scanlon D, Lee R, Soltero E, Parker N, McNeill L, Ledoux T, McIsaac JL, MacLeod K, Ata N, Jarvis S, Kirk S, Purtle J, Dodson E, Brownson R, Mittman B, Curran G, Curran G, Pyne J, Aarons G, Ehrhart M, Torres E, Miech E, Miech E, Stevens K; I.S.R.N. Steering Council, Hamilton A, Cohen D, Padgett D, Morshed A, Patel R, Prusaczyk B, Aron DC, Gupta D, Ball S, Hand R, Abram J, Wolfram T, Hastings M, Moreland-Russell S, Tabak R, Ramsey A, Baumann A, Kryzer E, Montgomery K, Lewis E, Padek M, Powell B, Brownson R, Mamaril CB, Mays G, Branham K, Timsina L, Mays G, Hogg R, Fagan A, Shapiro V, Brown E, Haggerty K, Hawkins D, Oesterle S, Hawkins D, Catalano R, McKay V, Dolcini MM, Hoffer L, Moin T, Li J, Duru OK, Ettner S, Turk N, Chan C, Keckhafer A, Luchs R, Ho S, Mangione C, Selby P, Zawertailo L, Minian N, Balliunas D, Dragonetti R, Hussain S, Lecce J, Chinman M, Acosta J, Ebener P, Malone PS, Slaughter M, Freedman D, Flocke S, Lee E, Matlack K, Trapl E, Ohri-Vachaspati P, Taggart M, Borawski E, Parrish A, Harris J, Kohn M, Hammerback K, McMillan B, Hannon P, Swindle T, Curran G, Whiteside-Mansell L, Ward W, Holt C, Santos SL, Tagai E, Scheirer MA, Carter R, Bowie J, Haider M, Slade J, Wang MQ, Masica A, Ogola G, Berryman C, Richter K, Shelton R, Jandorf L, Erwin D, Truong K, Javier JR, Coffey D, Schrager SM, Palinkas L, Miranda J, Johnson V, Hutcherson V, Ellis R, Kharmats A, Marshall-King S, LaPradd M, Fonseca-Becker F, Kepka D, Bodson J, Warner E, Fowler B, Shenkman E, Hogan W, Odedina F, De Leon J, Hooper M, Carrasquillo O, Reams R, Hurt M, Smith S, Szapocznik J, Nelson D, Mandal P, Teufel J. Chambers D, et al. Implement Sci. 2016 Aug 1;11 Suppl 2(Suppl 2):100. doi: 10.1186/s13012-016-0452-0. Implement Sci. 2016. PMID: 27490260 Free PMC article.
Steering Council S52 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - The value of qualitative methods in implementation research Alison Hamilton S53 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - Lear …
Steering Council S52 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - The value of qualitative methods in …
Identifying Frameworks for Validation and Monitoring of Consensual Behavioral Intervention Technologies: Narrative Review.
Carbonnel F, Ninot G. Carbonnel F, et al. J Med Internet Res. 2019 Oct 16;21(10):e13606. doi: 10.2196/13606. J Med Internet Res. 2019. PMID: 31621638 Free PMC article. Review.
The frameworks were then categorized based on (1) translational research thanks to a continuum of steps and (2) the three paradigms that may have inspired the frameworks: biomedical, engineering, and/or behavioral. ...Three dangerous scenarios are possible: (1) anar …
The frameworks were then categorized based on (1) translational research thanks to a continuum of steps and (2) the three para …
Broad-scale informed consent: A survey of the CTSA landscape.
Chandler R, Brady KT, Jerome RN, Eder M, Rothwell E, Brownley KA, Harris PA. Chandler R, et al. J Clin Transl Sci. 2019 Sep 23;3(5):253-260. doi: 10.1017/cts.2019.397. eCollection 2019 Oct. J Clin Transl Sci. 2019. PMID: 31660250 Free PMC article.
INTRODUCTION: Research opportunities associated with the proliferation of the electronic health record (EHR), big data initiatives, and innovative approaches to trial design can present challenges for obtaining and documenting informed consent. Broad-s …
INTRODUCTION: Research opportunities associated with the proliferation of the electronic health record (EHR), big da
Translating the therapeutic potential of neurotrophic factors to clinical 'proof of concept': a personal saga achieving a career-long quest.
Bartus RT. Bartus RT. Neurobiol Dis. 2012 Nov;48(2):153-78. doi: 10.1016/j.nbd.2012.04.004. Epub 2012 Apr 16. Neurobiol Dis. 2012. PMID: 22525569 Review.
Because of growing interest in translational R&D, including its practice in industry, the paper is uniquely oriented from the author's personal, quasi-autobiographic perspective and career-long experiences conducting translational research a …
Because of growing interest in translational R&D, including its practice in industry, the paper is uniquely oriented from the aut …
Transdisciplinary synthesis for ecosystem science, policy and management: The Australian experience.
Lynch AJ, Thackway R, Specht A, Beggs PJ, Brisbane S, Burns EL, Byrne M, Capon SJ, Casanova MT, Clarke PA, Davies JM, Dovers S, Dwyer RG, Ens E, Fisher DO, Flanigan M, Garnier E, Guru SM, Kilminster K, Locke J, Mac Nally R, McMahon KM, Mitchell PJ, Pierson JC, Rodgers EM, Russell-Smith J, Udy J, Waycott M. Lynch AJ, et al. Sci Total Environ. 2015 Nov 15;534:173-84. doi: 10.1016/j.scitotenv.2015.04.100. Epub 2015 May 6. Sci Total Environ. 2015. PMID: 25957785
These centres are finding an expanding role due to ever-accumulating data and the need for more and better opportunities to develop transdisciplinary and holistic approaches to solve real-world problems. ...Such centres provide analysis and synthesis opportunitie
These centres are finding an expanding role due to ever-accumulating data and the need for more and better opportunities to de …
"What Goes Around Comes Around": Lessons Learned from Economic Evaluations of Personalized Medicine Applied to Digital Medicine.
Phillips KA, Douglas MP, Trosman JR, Marshall DA. Phillips KA, et al. Value Health. 2017 Jan;20(1):47-53. doi: 10.1016/j.jval.2016.08.736. Value Health. 2017. PMID: 28212968 Free PMC article.
BACKGROUND: The growth of "big data" and the emphasis on patient-centered health care have led to the increasing use of two key technologies: personalized medicine and digital medicine. ...CONCLUSIONS: We conclude that more evidence on the effectiveness of digital m …
BACKGROUND: The growth of "big data" and the emphasis on patient-centered health care have led to the increasing use of two ke …
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