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The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis.
Somoskovi A, Parsons LM, Salfinger M. Somoskovi A, et al. Respir Res. 2001;2(3):164-8. doi: 10.1186/rr54. Epub 2001 Apr 5. Respir Res. 2001. PMID: 11686881 Free PMC article. Review.
In many countries and regions, these resistant strains constitute a serious threat to the efficacy of tuberculosis control programs. ...
In many countries and regions, these resistant strains constitute a serious threat to the efficacy of tuberculosis control programs. …
[Tuberculosis due to multidrug resistant Mycobacterium tuberculosis Beijing genotype identified by DNA fingerprinting: the first case identified in Hungary].
Lukács J, Sör E, Bohács A, Tolnay E, Bártfai Z, Várdi-Visy K, Somoskövi A. Lukács J, et al. Orv Hetil. 2005 Aug 28;146(35):1833-7. Orv Hetil. 2005. PMID: 16187543 Hungarian.
In a 28 years old Mongolian woman in whom pulmonary tuberculosis was diagnosed a poly- and multidrug (isoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin) resistant Mycobacterium tuberculosis was isolated from sputum in 2002. Since the patient was from …
In a 28 years old Mongolian woman in whom pulmonary tuberculosis was diagnosed a poly- and multidrug (isoniazid, rifampicin, p …
[Therapy in tuberculosis].
Somoskövi A, Lantos A. Somoskövi A, et al. Orv Hetil. 2004 Apr 18;145(16):871-3. Orv Hetil. 2004. PMID: 15156693 Review. Hungarian. No abstract available.
Diagnostic implications of inconsistent results obtained with the Xpert MTB/Rif assay in detection of Mycobacterium tuberculosis isolates with an rpoB mutation associated with low-level rifampin resistance.
Somoskovi A, Deggim V, Ciardo D, Bloemberg GV. Somoskovi A, et al. J Clin Microbiol. 2013 Sep;51(9):3127-9. doi: 10.1128/JCM.01377-13. Epub 2013 Jul 12. J Clin Microbiol. 2013. PMID: 23850949 Free PMC article.
Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs.
Schaller A, Sun Z, Yang Y, Somoskovi A, Zhang Y. Schaller A, et al. Antimicrob Agents Chemother. 2002 Aug;46(8):2636-9. doi: 10.1128/aac.46.8.2636-2639.2002. Antimicrob Agents Chemother. 2002. PMID: 12121945 Free PMC article.
Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), an …
Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (ant …
Direct comparison of the genotype MTBC and genomic deletion assays in terms of ability to distinguish between members of the Mycobacterium tuberculosis complex in clinical isolates and in clinical specimens.
Somoskovi A, Dormandy J, Rivenburg J, Pedrosa M, McBride M, Salfinger M. Somoskovi A, et al. J Clin Microbiol. 2008 May;46(5):1854-7. doi: 10.1128/JCM.00105-07. Epub 2008 Mar 19. J Clin Microbiol. 2008. PMID: 18353933 Free PMC article.
Discrepant results between pyrazinamide susceptibility testing by the reference BACTEC 460TB method and pncA DNA sequencing in patients infected with multidrug-resistant W-Beijing Mycobacterium tuberculosis strains.
Dormandy J, Somoskovi A, Kreiswirth BN, Driscoll JR, Ashkin D, Salfinger M. Dormandy J, et al. Chest. 2007 Feb;131(2):497-501. doi: 10.1378/chest.06-1899. Chest. 2007. PMID: 17296653
METHODS: The present study examined a large number of multidrug-resistant strain-W isolates (isolates of 29 patients) by susceptibility testing for pyrazinamide (PZA) using the reference BACTEC 460TB method (Becton Dickinson Diagnostic Instrument Systems; Sparks, MD) and a …
METHODS: The present study examined a large number of multidrug-resistant strain-W isolates (isolates of 29 patients) by susceptibili …
Sequencing of the pncA gene in members of the Mycobacterium tuberculosis complex has important diagnostic applications: Identification of a species-specific pncA mutation in "Mycobacterium canettii" and the reliable and rapid predictor of pyrazinamide resistance.
Somoskovi A, Dormandy J, Parsons LM, Kaswa M, Goh KS, Rastogi N, Salfinger M. Somoskovi A, et al. J Clin Microbiol. 2007 Feb;45(2):595-9. doi: 10.1128/JCM.01454-06. Epub 2006 Nov 29. J Clin Microbiol. 2007. PMID: 17135430 Free PMC article.
Testing for susceptibility to pyrazinamide (PZA) and analysis of the pncA gene sequences of 423 Mycobacterium tuberculosis complex isolates have revealed a unique silent nucleotide substitution that enables the rapid identification of "M. canettii" (proposed name). Moreove …
Testing for susceptibility to pyrazinamide (PZA) and analysis of the pncA gene sequences of 423 Mycobacterium tuberculosis complex isolates …
Use of smear-positive samples to assess the PCR-based genotype MTBDR assay for rapid, direct detection of the Mycobacterium tuberculosis complex as well as its resistance to isoniazid and rifampin.
Somoskovi A, Dormandy J, Mitsani D, Rivenburg J, Salfinger M. Somoskovi A, et al. J Clin Microbiol. 2006 Dec;44(12):4459-63. doi: 10.1128/JCM.01506-06. Epub 2006 Oct 11. J Clin Microbiol. 2006. PMID: 17035488 Free PMC article.
A total of 92 drug-resistant and 51 pansusceptible smear-positive specimens were included in the study. The Genotype MTBDR assay accurately and rapidly detected MTBC strains in 94.4% of the 143 specimens and showed a sensitivity of 94.4% for katG and 90.9% for rpoB
A total of 92 drug-resistant and 51 pansusceptible smear-positive specimens were included in the study. The Genotype MTBDR assay accu
Laboratory diagnostic aspects of drug resistant tuberculosis.
Parsons LM, Somoskövi A, Urbanczik R, Salfinger M. Parsons LM, et al. Front Biosci. 2004 Sep 1;9:2086-105. doi: 10.2741/1290. Front Biosci. 2004. PMID: 15353272 Review.
Multi-drug resistant strains of Mycobacterium tuberculosis (MDR-TB) are present world wide, and in many areas constitute a serious threat to the efficacy of TB control programs. ...Routine laboratory diagnosis of drug resistance in TB requires a viable, pure culture …
Multi-drug resistant strains of Mycobacterium tuberculosis (MDR-TB) are present world wide, and in many areas constitute a serious th …
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