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Melittin inhibits vascular smooth muscle cell proliferation through induction of apoptosis via suppression of nuclear factor-kappaB and Akt activation and enhancement of apoptotic protein expression.
Son DJ, Ha SJ, Song HS, Lim Y, Yun YP, Lee JW, Moon DC, Park YH, Park BS, Song MJ, Hong JT. Son DJ, et al. Among authors: Song HS, Song MJ. J Pharmacol Exp Ther. 2006 May;317(2):627-34. doi: 10.1124/jpet.105.095901. Epub 2006 Jan 9. J Pharmacol Exp Ther. 2006. PMID: 16401728
Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor kappaB.
Son DJ, Park MH, Chae SJ, Moon SO, Lee JW, Song HS, Moon DC, Kang SS, Kwon YE, Hong JT. Son DJ, et al. Among authors: Song HS. Mol Cancer Ther. 2007 Feb;6(2):675-83. doi: 10.1158/1535-7163.MCT-06-0328. Mol Cancer Ther. 2007. PMID: 17308063
Melittin, a major bioactive component of bee venom toxin, inhibits PDGF receptor beta-tyrosine phosphorylation and downstream intracellular signal transduction in rat aortic vascular smooth muscle cells.
Son DJ, Kang J, Kim TJ, Song HS, Sung KJ, Yun DY, Hong JT. Son DJ, et al. Among authors: Song HS. J Toxicol Environ Health A. 2007 Aug;70(15-16):1350-5. doi: 10.1080/15287390701428689. J Toxicol Environ Health A. 2007. PMID: 17654254
Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway.
Jo M, Park MH, Kollipara PS, An BJ, Song HS, Han SB, Kim JH, Song MJ, Hong JT. Jo M, et al. Among authors: Song HS, Song MJ. Toxicol Appl Pharmacol. 2012 Jan 1;258(1):72-81. doi: 10.1016/j.taap.2011.10.009. Epub 2011 Oct 15. Toxicol Appl Pharmacol. 2012. PMID: 22027265
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