A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.
Songyang Z, Gish G, Mbamalu G, Pawson T, Cantley LC.
Songyang Z, et al.
J Biol Chem. 1995 Nov 3;270(44):26029-32. doi: 10.1074/jbc.270.44.26029.
J Biol Chem. 1995.
PMID: 7592796
Free article.
Based on the phosphopeptide specificity and crystal structures, SH2 domains were classified into four different groups (Songyang, Z., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W. ...The beta D5 residues of SH2 domains were predicted to be critical …
Based on the phosphopeptide specificity and crystal structures, SH2 domains were classified into four different groups (Songyang, …