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A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. Harrington LB, et al. Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24. Cell. 2017. PMID: 28844692 Free PMC article.
R2D2 leads the silencing trigger to mRNA's death star.
Pellino JL, Sontheimer EJ. Pellino JL, et al. Cell. 2003 Oct 17;115(2):132-3. doi: 10.1016/s0092-8674(03)00806-7. Cell. 2003. PMID: 14567910
Silence from within: endogenous siRNAs and miRNAs.
Sontheimer EJ, Carthew RW. Sontheimer EJ, et al. Cell. 2005 Jul 15;122(1):9-12. doi: 10.1016/j.cell.2005.06.030. Cell. 2005. PMID: 16009127 Review.
RNAi: RISC gets loaded.
Preall JB, Sontheimer EJ. Preall JB, et al. Cell. 2005 Nov 18;123(4):543-5. doi: 10.1016/j.cell.2005.11.006. Cell. 2005. PMID: 16286001
Origins and Mechanisms of miRNAs and siRNAs.
Carthew RW, Sontheimer EJ. Carthew RW, et al. Cell. 2009 Feb 20;136(4):642-55. doi: 10.1016/j.cell.2009.01.035. Cell. 2009. PMID: 19239886 Free PMC article. Review.
Invasive DNA, chopped and in the CRISPR.
Marraffini LA, Sontheimer EJ. Marraffini LA, et al. Structure. 2009 Jun 10;17(6):786-8. doi: 10.1016/j.str.2009.05.002. Structure. 2009. PMID: 19523896 Free PMC article.
Structural biology. Cascading into focus.
Zhang Y, Sontheimer EJ. Zhang Y, et al. Science. 2014 Sep 19;345(6203):1452-3. doi: 10.1126/science.1260026. Science. 2014. PMID: 25237089 No abstract available.
The Bacterial Origins of the CRISPR Genome-Editing Revolution.
Sontheimer EJ, Barrangou R. Sontheimer EJ, et al. Hum Gene Ther. 2015 Jul;26(7):413-24. doi: 10.1089/hum.2015.091. Hum Gene Ther. 2015. PMID: 26078042 Review.
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