Sorger PK - Search Results

1

A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity.

Palmer AC, Chidley C, Sorger PK. Palmer AC, et al. Among authors: sorger pk. Elife. 2019 Nov 19;8:e50036. doi: 10.7554/eLife.50036. Elife. 2019. PMID: 31742555 Free PMC article.

2

Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.

Foijer F, Albacker LA, Bakker B, Spierings DC, Yue Y, Xie SZ, Davis S, Lutum-Jehle A, Takemoto D, Hare B, Furey B, Bronson RT, Lansdorp PM, Bradley A, Sorger PK. Foijer F, et al. Among authors: sorger pk. Elife. 2017 Mar 20;6:e20873. doi: 10.7554/eLife.20873. Elife. 2017. PMID: 28318489 Free PMC article.

3

Measuring Cancer Drug Sensitivity and Resistance in Cultured Cells.

Niepel M, Hafner M, Chung M, Sorger PK. Niepel M, et al. Among authors: sorger pk. Curr Protoc Chem Biol. 2017 Jun 19;9(2):55-74. doi: 10.1002/cpch.21. Curr Protoc Chem Biol. 2017. PMID: 28628199 Free PMC article.

4

Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy.

Palmer AC, Sorger PK. Palmer AC, et al. Among authors: sorger pk. Cell. 2017 Dec 14;171(7):1678-1691.e13. doi: 10.1016/j.cell.2017.11.009. Cell. 2017. PMID: 29245013 Free PMC article.

5

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes.

Lin JR, Izar B, Wang S, Yapp C, Mei S, Shah PM, Santagata S, Sorger PK. Lin JR, et al. Among authors: sorger pk. Elife. 2018 Jul 11;7:e31657. doi: 10.7554/eLife.31657. Elife. 2018. PMID: 29993362 Free PMC article.

6

Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.

Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK. Wang H, et al. Among authors: sorger pk. Cell Syst. 2019 May 22;8(5):412-426.e7. doi: 10.1016/j.cels.2019.03.009. Epub 2019 May 8. Cell Syst. 2019. PMID: 31078528 Free PMC article.

7

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.

Chopra SS, Jenney A, Palmer A, Niepel M, Chung M, Mills C, Sivakumaren SC, Liu Q, Chen JY, Yapp C, Asara JM, Gray NS, Sorger PK. Chopra SS, et al. Among authors: sorger pk. Cell Syst. 2020 Jan 22;10(1):66-81.e11. doi: 10.1016/j.cels.2019.11.001. Epub 2019 Dec 4. Cell Syst. 2020. PMID: 31812693 Free PMC article.

8

Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks.

Lyashenko E, Niepel M, Dixit PD, Lim SK, Sorger PK, Vitkup D. Lyashenko E, et al. Among authors: sorger pk. Elife. 2020 Jan 21;9:e50342. doi: 10.7554/eLife.50342. Elife. 2020. PMID: 31961323 Free PMC article.

9

A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts.

Palmer AC, Plana D, Gao H, Korn JM, Yang G, Green J, Zhang X, Velazquez R, McLaughlin ME, Ruddy DA, Kowal C, Muszynski J, Bullock C, Rivera S, Rakiec DP, Elliott G, Fordjour P, Meyer R, Loo A, Kurth E, Engelman JA, Bitter H, Sellers WR, Williams JA, Sorger PK. Palmer AC, et al. Among authors: sorger pk. Cancer Res. 2020 Oct 1;80(19):4278-4287. doi: 10.1158/0008-5472.CAN-19-3850. Epub 2020 Aug 3. Cancer Res. 2020. PMID: 32747364 Free PMC article.

10

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.

Gerosa L, Chidley C, Fröhlich F, Sanchez G, Lim SK, Muhlich J, Chen JY, Vallabhaneni S, Baker GJ, Schapiro D, Atanasova MI, Chylek LA, Shi T, Yi L, Nicora CD, Claas A, Ng TSC, Kohler RH, Lauffenburger DA, Weissleder R, Miller MA, Qian WJ, Wiley HS, Sorger PK. Gerosa L, et al. Among authors: sorger pk. Cell Syst. 2020 Nov 18;11(5):478-494.e9. doi: 10.1016/j.cels.2020.10.002. Epub 2020 Oct 27. Cell Syst. 2020. PMID: 33113355 Free PMC article.

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