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Endocytosis and intracellular trafficking of ErbBs.
Sorkin A, Goh LK. Sorkin A, et al. Exp Cell Res. 2009 Feb 15;315(4):683-96. doi: 10.1016/j.yexcr.2008.07.029. Exp Cell Res. 2009. PMID: 19278030 Review.
Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes.
Pinilla-Macua I, Watkins SC, Sorkin A. Pinilla-Macua I, et al. Among authors: sorkin a. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2122-7. doi: 10.1073/pnas.1520301113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858456 Free PMC article.
Cell surface biotinylation and selective inactivation of surface EGFRs suggested that a small fraction of active EGFRs remaining in the plasma membrane is responsible for continuous signaling to MEK1/2 and ERK1/2. ...However, sustained minimal activation of Ras by a
Cell surface biotinylation and selective inactivation of surface EGFRs suggested that a small fraction of active EGFRs remaining in t …
Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis.
Fortian A, Sorkin A. Fortian A, et al. Among authors: sorkin a. J Cell Sci. 2014 Jan 15;127(Pt 2):432-44. doi: 10.1242/jcs.137786. Epub 2013 Nov 20. J Cell Sci. 2014. PMID: 24259669 Free PMC article.
Activation of epidermal growth factor (EGF) receptor (EGFR) leads to its interaction with Grb2, a dual-function adapter mediating both signaling through Ras and receptor endocytosis. ...Therefore, we hypothesize that a single EGFR molecule can be simultaneously asso …
Activation of epidermal growth factor (EGF) receptor (EGFR) leads to its interaction with Grb2, a dual-function adapter mediating bot …
EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo.
Pinilla-Macua I, Grassart A, Duvvuri U, Watkins SC, Sorkin A. Pinilla-Macua I, et al. Among authors: sorkin a. Elife. 2017 Dec 21;6:e31993. doi: 10.7554/eLife.31993. Elife. 2017. PMID: 29268862 Free PMC article.
Despite a well-established role for the epidermal growth factor receptor (EGFR) in tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. ...Collectively, our data suggest that a small pool of active EGFRs is sufficient to drive tumo …
Despite a well-established role for the epidermal growth factor receptor (EGFR) in tumorigenesis, EGFR activities and endocytosis in …
Brain Region-Specific Trafficking of the Dopamine Transporter.
Block ER, Nuttle J, Balcita-Pedicino JJ, Caltagarone J, Watkins SC, Sesack SR, Sorkin A. Block ER, et al. Among authors: sorkin a. J Neurosci. 2015 Sep 16;35(37):12845-58. doi: 10.1523/JNEUROSCI.1391-15.2015. J Neurosci. 2015. PMID: 26377471 Free PMC article.
Hence, we performed immunolabeling and quantitative analysis of the subcellular and regional distribution of DAT using the transgenic knock-in mouse expressing hemagglutinin (HA) epitope-tagged DAT (HA-DAT) and by using a combination of electron microscopy and a nov …
Hence, we performed immunolabeling and quantitative analysis of the subcellular and regional distribution of DAT using the transgenic knock- …
Methods to study endocytic trafficking of the EGF receptor.
Pinilla-Macua I, Sorkin A. Pinilla-Macua I, et al. Among authors: sorkin a. Methods Cell Biol. 2015;130:347-67. doi: 10.1016/bs.mcb.2015.05.008. Epub 2015 Jul 7. Methods Cell Biol. 2015. PMID: 26360045 Free PMC article.
Basic experimental protocols described in this chapter cover a combination of single-cell microscopy and biochemical methods that are used to follow EGF-induced endocytosis of EGFR in real time, measure the kinetic rate parameters of EGFR internalization and recycling, and …
Basic experimental protocols described in this chapter cover a combination of single-cell microscopy and biochemical methods that are …
Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation.
Fortian A, Dionne LK, Hong SH, Kim W, Gygi SP, Watkins SC, Sorkin A. Fortian A, et al. Among authors: sorkin a. Traffic. 2015 Nov;16(11):1137-54. doi: 10.1111/tra.12314. Epub 2015 Sep 9. Traffic. 2015. PMID: 26251007 Free PMC article.
Total internal reflection fluorescence microscopy imaging of HuTu-80 cells transfected with labeled ubiquitin adaptor epsin1 demonstrated that the ubiquitylation-deficient EGFR mutant was endocytosed through a limited population of epsin-enriched clathrin-coated pits (CCPs …
Total internal reflection fluorescence microscopy imaging of HuTu-80 cells transfected with labeled ubiquitin adaptor epsin1 demonstrated th …
Endocytosis of receptor tyrosine kinases.
Goh LK, Sorkin A. Goh LK, et al. Among authors: sorkin a. Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a017459. doi: 10.1101/cshperspect.a017459. Cold Spring Harb Perspect Biol. 2013. PMID: 23637288 Free PMC article. Review.
The endocytosis of epidermal growth factor in A431 cells: a pH of microenvironment and the dynamics of receptor complex dissociation.
Sorkin AD, Teslenko LV, Nikolsky NN. Sorkin AD, et al. Exp Cell Res. 1988 Mar;175(1):192-205. doi: 10.1016/0014-4827(88)90266-2. Exp Cell Res. 1988. PMID: 2894318
Using microscope spectrofluorometer, we determined that the Tr-FITC-containing para-Golgi structures have a pH of 6.1 +/- 0.3 while lysosomes containing dextran-fluorescein have a pH of 5.0 +/- 0.2. ...A prolonged presence of EGF-receptor complexes in the par …
Using microscope spectrofluorometer, we determined that the Tr-FITC-containing para-Golgi structures have a pH of 6.1 +/- 0.3 while l …
Days and knights discussing membrane dynamics in endocytosis: meeting report from the Euresco/EMBL Membrane Dynamics in Endocytosis, 6--11 October in Tomar, Portugal.
Schmid SL, Sorkin AD. Schmid SL, et al. Among authors: sorkin ad. Traffic. 2002 Jan;3(1):77-85. Traffic. 2002. PMID: 11872146
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