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209 results
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Power surge: supporting cells "fuel" cancer cell mitochondria.
Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Martinez-Outschoorn UE, et al. Among authors: sotgia f. Cell Metab. 2012 Jan 4;15(1):4-5. doi: 10.1016/j.cmet.2011.12.011. Cell Metab. 2012. PMID: 22225869
Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells.
Williams TM, Sotgia F, Lee H, Hassan G, Di Vizio D, Bonuccelli G, Capozza F, Mercier I, Rui H, Pestell RG, Lisanti MP. Williams TM, et al. Among authors: sotgia f. Am J Pathol. 2006 Nov;169(5):1784-801. doi: 10.2353/ajpath.2006.060590. Am J Pathol. 2006. PMID: 17071600 Free PMC article.
Localized treatment with a novel FDA-approved proteasome inhibitor blocks the degradation of dystrophin and dystrophin-associated proteins in mdx mice.
Bonuccelli G, Sotgia F, Capozza F, Gazzerro E, Minetti C, Lisanti MP. Bonuccelli G, et al. Among authors: sotgia f. Cell Cycle. 2007 May 15;6(10):1242-8. doi: 10.4161/cc.6.10.4182. Epub 2007 May 27. Cell Cycle. 2007. PMID: 17495527
Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation.
Mercier I, Bryant KG, Sotgia F, Bonuccelli G, Witkiewicz AK, Dasgupta A, Jasmin JF, Pestell RG, Lisanti MP. Mercier I, et al. Among authors: sotgia f. Cell Cycle. 2009 May 1;8(9):1396-401. doi: 10.4161/cc.8.9.8307. Epub 2009 May 26. Cell Cycle. 2009. PMID: 19342880
Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.
Bonuccelli G, Casimiro MC, Sotgia F, Wang C, Liu M, Katiyar S, Zhou J, Dew E, Capozza F, Daumer KM, Minetti C, Milliman JN, Alpy F, Rio MC, Tomasetto C, Mercier I, Flomenberg N, Frank PG, Pestell RG, Lisanti MP. Bonuccelli G, et al. Among authors: sotgia f. Am J Pathol. 2009 May;174(5):1650-62. doi: 10.2353/ajpath.2009.080648. Am J Pathol. 2009. PMID: 19395651 Free PMC article.
Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy.
Witkiewicz AK, Casimiro MC, Dasgupta A, Mercier I, Wang C, Bonuccelli G, Jasmin JF, Frank PG, Pestell RG, Kleer CG, Sotgia F, Lisanti MP. Witkiewicz AK, et al. Among authors: sotgia f. Cell Cycle. 2009 Jun 1;8(11):1654-8. doi: 10.4161/cc.8.11.8544. Cell Cycle. 2009. PMID: 19448435
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma.
Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Pavlides S, et al. Among authors: sotgia f. Cell Cycle. 2009 Dec;8(23):3984-4001. doi: 10.4161/cc.8.23.10238. Epub 2009 Dec 5. Cell Cycle. 2009. PMID: 19923890
Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling".
Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, Martinez-Outschoorn UE, Howell A, Sotgia F, Lisanti MP. Pavlides S, et al. Among authors: sotgia f. Aging (Albany NY). 2010 Apr;2(4):185-99. doi: 10.18632/aging.100134. Aging (Albany NY). 2010. PMID: 20442453 Free PMC article.
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Witkiewicz AK, Vander Heiden MG, Migneco G, Chiavarina B, Frank PG, Capozza F, Flomenberg N, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Bonuccelli G, et al. Among authors: sotgia f. Cell Cycle. 2010 May 15;9(10):1960-71. doi: 10.4161/cc.9.10.11601. Epub 2010 May 15. Cell Cycle. 2010. PMID: 20495363
Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.
Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Pavlides S, et al. Among authors: sotgia f. Cell Cycle. 2010 Jun 1;9(11):2201-19. doi: 10.4161/cc.9.11.11848. Cell Cycle. 2010. PMID: 20519932
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