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mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.
Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V. Van Skike CE, et al. Among authors: soto vy. Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6. Aging Cell. 2020. PMID: 31693798 Free PMC article.
Rapamycin extends life and health in C57BL/6 mice.
Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, Réndon S, van Remmen H, Ward W, Javors M, Richardson A, Austad SN, Fischer K. Zhang Y, et al. J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):119-30. doi: 10.1093/gerona/glt056. Epub 2013 May 16. J Gerontol A Biol Sci Med Sci. 2014. PMID: 23682161 Free PMC article.
Sco2 deficient mice develop increased adiposity and insulin resistance.
Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H. Hill S, et al. Among authors: soto vy. Mol Cell Endocrinol. 2017 Nov 5;455:103-114. doi: 10.1016/j.mce.2017.03.019. Epub 2017 Apr 18. Mol Cell Endocrinol. 2017. PMID: 28428045 Free PMC article.