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mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.
Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6.
Aging Cell. 2020.
PMID: 31693798
Free PMC article.
A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated.
Fischer KE, Hoffman JM, Sloane LB, Gelfond JA, Soto VY, Richardson AG, Austad SN.
Fischer KE, et al. Among authors: soto vy.
Aging (Albany NY). 2016 Oct 2;8(10):2370-2391. doi: 10.18632/aging.101059.
Aging (Albany NY). 2016.
PMID: 27705904
Free PMC article.
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Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.
Fischer KE, Gelfond JA, Soto VY, Han C, Someya S, Richardson A, Austad SN.
Fischer KE, et al. Among authors: soto vy.
PLoS One. 2015 May 15;10(5):e0126644. doi: 10.1371/journal.pone.0126644. eCollection 2015.
PLoS One. 2015.
PMID: 25978367
Free PMC article.
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Rapamycin extends life and health in C57BL/6 mice.
Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, Réndon S, van Remmen H, Ward W, Javors M, Richardson A, Austad SN, Fischer K.
Zhang Y, et al.
J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):119-30. doi: 10.1093/gerona/glt056. Epub 2013 May 16.
J Gerontol A Biol Sci Med Sci. 2014.
PMID: 23682161
Free PMC article.
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Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice.
Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB.
Zhang Y, et al.
Arch Biochem Biophys. 2015 Jun 15;576:39-48. doi: 10.1016/j.abb.2014.12.018. Epub 2015 Jan 3.
Arch Biochem Biophys. 2015.
PMID: 25558793
Free PMC article.
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Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.
Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H.
Deepa SS, et al.
Aging Cell. 2018 Aug;17(4):e12769. doi: 10.1111/acel.12769. Epub 2018 Apr 25.
Aging Cell. 2018.
PMID: 29696791
Free PMC article.
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Sco2 deficient mice develop increased adiposity and insulin resistance.
Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H.
Hill S, et al. Among authors: soto vy.
Mol Cell Endocrinol. 2017 Nov 5;455:103-114. doi: 10.1016/j.mce.2017.03.019. Epub 2017 Apr 18.
Mol Cell Endocrinol. 2017.
PMID: 28428045
Free PMC article.
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