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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.
Pybus BS, Marcsisin SR, Jin X, Deye G, Sousa JC, Li Q, Caridha D, Zeng Q, Reichard GA, Ockenhouse C, Bennett J, Walker LA, Ohrt C, Melendez V. Pybus BS, et al. Among authors: sousa jc. Malar J. 2013 Jun 20;12:212. doi: 10.1186/1475-2875-12-212. Malar J. 2013. PMID: 23782898 Free PMC article.
Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.
Marcsisin SR, Sousa JC, Reichard GA, Caridha D, Zeng Q, Roncal N, McNulty R, Careagabarja J, Sciotti RJ, Bennett JW, Zottig VE, Deye G, Li Q, Read L, Hickman M, Dhammika Nanayakkara NP, Walker LA, Smith B, Melendez V, Pybus BS. Marcsisin SR, et al. Among authors: sousa jc. Malar J. 2014 Jan 3;13:2. doi: 10.1186/1475-2875-13-2. Malar J. 2014. PMID: 24386891 Free PMC article.
Differential CYP 2D6 metabolism alters primaquine pharmacokinetics.
Potter BM, Xie LH, Vuong C, Zhang J, Zhang P, Duan D, Luong TL, Bandara Herath HM, Dhammika Nanayakkara NP, Tekwani BL, Walker LA, Nolan CK, Sciotti RJ, Zottig VE, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Marcsisin SR. Potter BM, et al. Among authors: sousa jc. Antimicrob Agents Chemother. 2015 Apr;59(4):2380-7. doi: 10.1128/AAC.00015-15. Epub 2015 Feb 2. Antimicrob Agents Chemother. 2015. PMID: 25645856 Free PMC article.
Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.
Vuong C, Xie LH, Potter BM, Zhang J, Zhang P, Duan D, Nolan CK, Sciotti RJ, Zottig VE, Nanayakkara NP, Tekwani BL, Walker LA, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Smith B, Marcsisin SR. Vuong C, et al. Among authors: sousa jc. Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9. doi: 10.1128/AAC.00343-15. Epub 2015 Apr 13. Antimicrob Agents Chemother. 2015. PMID: 25870069 Free PMC article.
Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs.
Wickham KS, Baresel PC, Marcsisin SR, Sousa J, Vuong CT, Reichard GA, Campo B, Tekwani BL, Walker LA, Rochford R. Wickham KS, et al. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5906-13. doi: 10.1128/AAC.00600-16. Print 2016 Oct. Antimicrob Agents Chemother. 2016. PMID: 27458212 Free PMC article.
273 results