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Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome.
Guzzi N, Muthukumar S, Cieśla M, Todisco G, Ngoc PCT, Madej M, Munita R, Fazio S, Ekström S, Mortera-Blanco T, Jansson M, Nannya Y, Cazzola M, Ogawa S, Malcovati L, Hellström-Lindberg E, Dimitriou M, Bellodi C. Guzzi N, et al. Among authors: muthukumar s. Nat Cell Biol. 2022 Mar;24(3):299-306. doi: 10.1038/s41556-022-00852-9. Epub 2022 Mar 15. Nat Cell Biol. 2022. PMID: 35292784 Free PMC article.
The NBDY Microprotein Regulates Cellular RNA Decapping.
Na Z, Luo Y, Schofield JA, Smelyansky S, Khitun A, Muthukumar S, Valkov E, Simon MD, Slavoff SA. Na Z, et al. Among authors: muthukumar s. Biochemistry. 2020 Oct 27;59(42):4131-4142. doi: 10.1021/acs.biochem.0c00672. Epub 2020 Oct 15. Biochemistry. 2020. PMID: 33059440 Free PMC article.
A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia.
Eldeeb M, Yuan O, Guzzi N, Thi Ngoc PC, Konturek-Ciesla A, Kristiansen TA, Muthukumar S, Magee J, Bellodi C, Yuan J, Bryder D. Eldeeb M, et al. Among authors: muthukumar s. Cell Rep. 2023 Feb 9;42(2):112099. doi: 10.1016/j.celrep.2023.112099. Online ahead of print. Cell Rep. 2023. PMID: 36763502 Free article.
Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion.
Verma G, Bowen A, Gheibi S, Hamilton A, Muthukumar S, Cataldo LR, Asplund O, Esguerra J, Karagiannopoulos A, Lyons C, Cowan E, Bellodi C, Prasad R, Fex M, Mulder H. Verma G, et al. Among authors: muthukumar s. J Biol Chem. 2022 Mar;298(3):101692. doi: 10.1016/j.jbc.2022.101692. Epub 2022 Feb 8. J Biol Chem. 2022. PMID: 35148993 Free PMC article.
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer.
Cieśla M, Ngoc PCT, Cordero E, Martinez ÁS, Morsing M, Muthukumar S, Beneventi G, Madej M, Munita R, Jönsson T, Lövgren K, Ebbesson A, Nodin B, Hedenfalk I, Jirström K, Vallon-Christersson J, Honeth G, Staaf J, Incarnato D, Pietras K, Bosch A, Bellodi C. Cieśla M, et al. Among authors: muthukumar s. Mol Cell. 2021 Apr 1;81(7):1453-1468.e12. doi: 10.1016/j.molcel.2021.01.034. Epub 2021 Mar 3. Mol Cell. 2021. PMID: 33662273 Free article.
Mechanism of chiral proofreading during translation of the genetic code.
Ahmad S, Routh SB, Kamarthapu V, Chalissery J, Muthukumar S, Hussain T, Kruparani SP, Deshmukh MV, Sankaranarayanan R. Ahmad S, et al. Among authors: muthukumar s. Elife. 2013 Dec 3;2:e01519. doi: 10.7554/eLife.01519. Elife. 2013. PMID: 24302572 Free PMC article.
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