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[Monitoring markers of bone turnover in multiple myeloma].
Spicka I, Spacek P, Hulejová H, Procházka B, Cieslar P, Chrz M, Válková V, Klener P. Spicka I, et al. Vnitr Lek. 1999 Aug;45(8):463-7. Vnitr Lek. 1999. PMID: 11045145 Czech.

Significant correlation was found between PYR and DPYR levels (p < 0.001) and between DPYR and OC (p < 0.05). Significantly higher urine PYR and DPYR (p < 0.001 and p < 0.01, respectively), but not serum OC, were found in myeloma comparing

Significant correlation was found between PYR and DPYR levels (p < 0.001) and between DPYR and OC (p < 0.05). Significan

[Changes in the articular compartment in advanced osteoarthritis].
Hulejová H, Spacek P, Klézl Z, Trc T, Adam M. Hulejová H, et al. Acta Chir Orthop Traumatol Cech. 2003;70(4):248-52. Acta Chir Orthop Traumatol Cech. 2003. PMID: 14569863 Czech.
[Relation between cytokines, adhesive immunoglobulins and matrix metalloproteinases in osteoarthritic joints].
St'ovícková J, Hulejová H, Pesáková V, Spacek P, Klezl Z, Trc T, Adam M. St'ovícková J, et al. Cas Lek Cesk. 2002 Aug 30;141(17):555-60. Cas Lek Cesk. 2002. PMID: 12404960 Czech.

In cartilage and synovial fluid the proteolytic potential of metalloproteinases was balanced with high concentrations of their inhibitor TIMP-1 (259.4 +/- 105.2 pmol/g protein vs 2343.8 +/- 637.5 pmol/g protein in synovial fluid, p < 0.00001, and 178.9 +/- 175.7 pmol/g

In cartilage and synovial fluid the proteolytic potential of metalloproteinases was balanced with high concentrations of their inhibitor TIM …
Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis.
Pavelka K, Forejtová S, Olejárová M, Gatterová J, Senolt L, Spacek P, Braun M, Hulejová M, Stovícková J, Pavelková A. Pavelka K, et al. Osteoarthritis Cartilage. 2004 Apr;12(4):277-83. doi: 10.1016/j.joca.2004.01.001. Osteoarthritis Cartilage. 2004. PMID: 15023379
RESULTS: In the group of patients suffering from knee OA, higher serum levels of pentosidine (P=0.04), MMP-9 (P=0.02), TIMP (P=0.04) and COMP (P=0.05) were detected compared with healthy control subjects. Using a correlation analysis method, it has bee …
RESULTS: In the group of patients suffering from knee OA, higher serum levels of pentosidine (P=0.04), MMP-9 (P=0.02), TIMP ( …
Pentosidine in osteoarthritis: HPLC determination in body fluids and in tissues.
Spacek P, Adam M. Spacek P, et al. Rheumatol Int. 2006 Aug;26(10):923-7. doi: 10.1007/s00296-006-0105-8. Epub 2006 Mar 31. Rheumatol Int. 2006. PMID: 16575610
Advanced glycation end-products in patients with chronic alcohol misuse.
Kalousová M, Zima T, Popov P, Spacek P, Braun M, Soukupová J, Pelinkova K, Kientsch-Engel R. Kalousová M, et al. Alcohol Alcohol. 2004 Jul-Aug;39(4):316-20. doi: 10.1093/alcalc/agh058. Alcohol Alcohol. 2004. PMID: 15208163

RESULTS: AGE fluorescence was significantly higher in chronic alcoholic patients than in healthy subjects (4.3 +/- 0.7 x 10(3) vs 3.7 +/- 0.5 x 10(3) AU/g protein, P < 0.005), while CML was only slightly but not significantly elevated (569.1 +/- 106.6 vs 545.5 +/- 85.8

RESULTS: AGE fluorescence was significantly higher in chronic alcoholic patients than in healthy subjects (4.3 +/- 0.7 x 10(3) vs 3.7 +/- 0. …
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