Speck NA - Search Results

1

Tyrosyl phosphorylation toggles a Runx1 switch.

Neel BG, Speck NA. Neel BG, et al. Among authors: speck na. Genes Dev. 2012 Jul 15;26(14):1520-6. doi: 10.1101/gad.198051.112. Genes Dev. 2012. PMID: 22802526 Free PMC article.

2

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS. Gerhardt DM, et al. Genes Dev. 2014 Mar 15;28(6):576-93. doi: 10.1101/gad.227496.113. Genes Dev. 2014. PMID: 24637115 Free PMC article.

3

Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes.

Howell ED, Yzaguirre AD, Gao P, Lis R, He B, Lakadamyali M, Rafii S, Tan K, Speck NA. Howell ED, et al. Among authors: speck na. Genes Dev. 2021 Nov 1;35(21-22):1475-1489. doi: 10.1101/gad.348738.121. Epub 2021 Oct 21. Genes Dev. 2021. PMID: 34675061 Free PMC article.

4

RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils.

Zezulin AU, Yen D, Ye D, Howell ED, Bresciani E, Diemer J, Ren JG, Ahmad MH, Castilla LH, Touw IP, Minn AJ, Tong W, Liu PP, Tan K, Yu W, Speck NA. Zezulin AU, et al. Among authors: speck na. Genes Dev. 2023 Jul 1;37(13-14):605-620. doi: 10.1101/gad.350418.123. Epub 2023 Aug 3. Genes Dev. 2023. PMID: 37536952 Free PMC article.

5

Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.

Tober J, Yzaguirre AD, Piwarzyk E, Speck NA. Tober J, et al. Among authors: speck na. Development. 2013 Sep;140(18):3765-76. doi: 10.1242/dev.094961. Epub 2013 Aug 7. Development. 2013. PMID: 23924635 Free PMC article.

6

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.

Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Yzaguirre AD, Azzola L, Ng ES, Stanley EG, French DL, Cheng X, Gadue P, Speck NA, Elefanty AG, Keller G. Ditadi A, et al. Among authors: speck na. Nat Cell Biol. 2015 May;17(5):580-91. doi: 10.1038/ncb3161. Epub 2015 Apr 27. Nat Cell Biol. 2015. PMID: 25915127 Free PMC article.

7

Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis.

Yzaguirre AD, Howell ED, Li Y, Liu Z, Speck NA. Yzaguirre AD, et al. Among authors: speck na. Development. 2018 Jan 29;145(2):dev158162. doi: 10.1242/dev.158162. Development. 2018. PMID: 29361566 Free PMC article.

8

Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.

Chen MJ, Li Y, De Obaldia ME, Yang Q, Yzaguirre AD, Yamada-Inagawa T, Vink CS, Bhandoola A, Dzierzak E, Speck NA. Chen MJ, et al. Among authors: speck na. Cell Stem Cell. 2011 Dec 2;9(6):541-52. doi: 10.1016/j.stem.2011.10.003. Cell Stem Cell. 2011. PMID: 22136929 Free PMC article.

9

Runx1 loss minimally impacts long-term hematopoietic stem cells.

Cai X, Gaudet JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernst P, Speck NA. Cai X, et al. Among authors: speck na. PLoS One. 2011;6(12):e28430. doi: 10.1371/journal.pone.0028430. Epub 2011 Dec 1. PLoS One. 2011. PMID: 22145044 Free PMC article.

10

RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making.

Mangan JK, Speck NA. Mangan JK, et al. Among authors: speck na. Crit Rev Oncog. 2011;16(1-2):77-91. doi: 10.1615/critrevoncog.v16.i1-2.80. Crit Rev Oncog. 2011. PMID: 22150309 Free PMC article. Review.

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