Spector NL - Search Results

1

Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016.

Xia W, Liu LH, Ho P, Spector NL. Xia W, et al. Among authors: spector nl. Oncogene. 2004 Jan 22;23(3):646-53. doi: 10.1038/sj.onc.1207166. Oncogene. 2004. PMID: 14737100

2

Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.

Osada T, Hartman ZC, Wei J, Lei G, Hobeika AC, Gwin WR, Diniz MA, Spector N, Clay TM, Chen W, Morse MA, Lyerly HK. Osada T, et al. Breast Cancer Res. 2018 Aug 9;20(1):90. doi: 10.1186/s13058-018-1023-x. Breast Cancer Res. 2018. PMID: 30092835 Free PMC article.

3

Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibition [corrected].

Hamilton E, Blackwell K, Hobeika AC, Clay TM, Broadwater G, Ren XR, Chen W, Castro H, Lehmann F, Spector N, Wei J, Osada T, Lyerly HK, Morse MA. Hamilton E, et al. J Transl Med. 2012 Feb 10;10:28. doi: 10.1186/1479-5876-10-28. J Transl Med. 2012. PMID: 22325452 Free PMC article. Clinical Trial.

4

Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo.

Morse MA, Wei J, Hartman Z, Xia W, Ren XR, Lei G, Barry WT, Osada T, Hobeika AC, Peplinski S, Jiang H, Devi GR, Chen W, Spector N, Amalfitano A, Lyerly HK, Clay TM. Morse MA, et al. Int J Cancer. 2010 Jun 15;126(12):2893-903. doi: 10.1002/ijc.24995. Int J Cancer. 2010. PMID: 19856307 Free PMC article.

5

Treatment of metastatic ErbB2-positive breast cancer: options after progression on trastuzumab.

Spector N. Spector N. Clin Breast Cancer. 2008 Mar;8 Suppl 3:S94-9. doi: 10.3816/cbc.2008.s.005. Clin Breast Cancer. 2008. PMID: 18777948 Review.

6

Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers.

Xia W, Husain I, Liu L, Bacus S, Saini S, Spohn J, Pry K, Westlund R, Stein SH, Spector NL. Xia W, et al. Among authors: spector nl. Cancer Res. 2007 Feb 1;67(3):1170-5. doi: 10.1158/0008-5472.CAN-06-2101. Cancer Res. 2007. PMID: 17283152

7

A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer.

Xia W, Bacus S, Hegde P, Husain I, Strum J, Liu L, Paulazzo G, Lyass L, Trusk P, Hill J, Harris J, Spector NL. Xia W, et al. Among authors: spector nl. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7795-800. doi: 10.1073/pnas.0602468103. Epub 2006 May 8. Proc Natl Acad Sci U S A. 2006. PMID: 16682622 Free PMC article.

8

Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.

Xia W, Bisi J, Strum J, Liu L, Carrick K, Graham KM, Treece AL, Hardwicke MA, Dush M, Liao Q, Westlund RE, Zhao S, Bacus S, Spector NL. Xia W, et al. Among authors: spector nl. Cancer Res. 2006 Feb 1;66(3):1640-7. doi: 10.1158/0008-5472.CAN-05-2000. Cancer Res. 2006. PMID: 16452223

9

An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.

Xia W, Petricoin EF 3rd, Zhao S, Liu L, Osada T, Cheng Q, Wulfkuhle JD, Gwin WR, Yang X, Gallagher RI, Bacus S, Lyerly HK, Spector NL. Xia W, et al. Among authors: spector nl. Breast Cancer Res. 2013;15(5):R85. doi: 10.1186/bcr3480. Breast Cancer Res. 2013. PMID: 24044505 Free PMC article.

10

Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells.

Xia W, Gerard CM, Liu L, Baudson NM, Ory TL, Spector NL. Xia W, et al. Among authors: spector nl. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774. Oncogene. 2005. PMID: 16091755

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